| Identification | Back Directory | [Name]
SC 66 | [CAS]
871361-88-5 | [Synonyms]
SC 66
CS-2480
SC66;SC 66
(2E,6E)-2,6-Bis(4-pyridinylmethylene)-cyclohexanone
Cyclohexanone, 2,6-bis(4-pyridinylMethylene)-, (2E,6E)- | [Molecular Formula]
C18H16N2O | [MDL Number]
MFCD05025493 | [MOL File]
871361-88-5.mol | [Molecular Weight]
276.33 |
| Hazard Information | Back Directory | [Description]
Akt activation requires binding of its pleckstrin homology domain (PHD) to membrane-associated phosphatidylinositol-3,4,5-trisphosphate (PIP3) or phosphatidylinositol-3,4-bisphosphate (PIP2). Increased Akt activity, e.g., through a gain-of-function mutation in the PHD of Akt1, is pivotal to many types of cancer. Activated Akt may be regulated by various events, including ubiquitination-mediated deactivation. SC-66 is an allosteric inhibitor of Akt that facilitates both ubiquitination and deactivation of Akt. At 4 μg/ml, SC-66 inhibits Akt activity in HEK293T cells and in HEK293 cells stably expressing Akt with the gain-of-function pleckstrin homology domain mutation, promoting cell death. In nude mice inoculated with HEK293T cells, SC-66 (15 mg/kg) suppresses tumor growth. | [Uses]
SC 66 is an analog of curcumin that can inhibit the activity of ATP-binding cassette transporters in cancer multidrug resistance. | [storage]
-20°C |
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