| Identification | Back Directory | [Name]
SC-514 | [CAS]
354812-17-2 | [Synonyms]
SC-514
GK01140
GK-01140
GK 01140
SC-514, >=98%
IKK-2 Inhibitor, SC-514
4-Amino-[2,3']bithiophenyl-5-carboxamide
4-Amino-[2',3'-bithiophene]-5-carboxamide
[2,3'-Bithiophene]-5-carboxamide, 4-amino-
5-(Thien-3-yl)-3-aminothiophene-2-carboxamide
3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide
4-Amino-[2,3']bithiophenyl-5-carboxamide GK 01140
4-Amino-[2,3"]bithiophenyl-5-carboxylic acid amide | [Molecular Formula]
C9H8N2OS2 | [MDL Number]
MFCD00206459 | [MOL File]
354812-17-2.mol | [Molecular Weight]
224.303 |
| Chemical Properties | Back Directory | [Appearance]
Yellow Solid | [Melting point ]
209-211°C | [storage temp. ]
Store at +4°C | [solubility ]
DMSO: soluble10mg/mL, clear | [form ]
powder | [color ]
white to light brown | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| Hazard Information | Back Directory | [Chemical Properties]
Yellow Solid | [Uses]
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, | [Uses]
A cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 ~3-12 μM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IK | [Description]
SC-514 (354812-17-2) is a reversible, competitive inhibitor of IKK2 (IC50 = 11.2 μM). Has not been demonstrated to inhibit other IKK isoforms, or other kinases. SC-514 displays dose-dependent inhibition of the transcription of NF-κB dependent genes in cell culture.1 | [Definition]
ChEBI: 3-amino-5-(3-thiophenyl)-2-thiophenecarboxamide is a ring assembly and a member of thiophenes. | [storage]
Store at +4°C | [References]
1) Kishore et al. (2003), A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts; J. Biol. Chem., 278 32861 |
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