| Identification | Back Directory | [Name]
RITANSERIN | [CAS]
87051-43-2 | [Synonyms]
R 55667
Tiserton
RITANSERIN
RITANSERIN SEROTONIN ANTAGONIST
6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thia
6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimi
6-[2-[4-[BIS(4-FLUOROPHENYL)-METHYLENE]-1-PIPERIDINYL]-ETHYL]-5H-THIAZOLO[3,2-A]PYRIMIDIN-5-ONE
6-(2-(4-(Bis(4-fluorophenyl)methylene)piperidin-1-yl)-ethyl)-7-methyl-5H-thiazolo[3,2-a]pyrimidin
6-[2-[4-[Bis(4-fluorophenyl)methylene]-piperidino]ethyl]-7-methyl-5H-thiazolo-[3,2-a]pyrimidin-5-one
6-[2-[4-[Bis(4-fluorophenyl)methylene]piperidin-1-yl]ethyl]-7-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one
6-[2-[4-(bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-5h-thiazolo[3,2-a]pyrimidin-5-one
6-(2-[4-(BIS[4-FLUOROPHENYL]METHYLENE)-1-PIPERIDINYL]ETHYL)-7-METHYL-5H-THIAZOLO(3,2-A)PYRIMIDIN-5-ONE
5H-Thiazolo[3,2-a]pyrimidin-5-one, 6-[2-[4-[bis(4-fluorophenyl)methylene]-1-piperidinyl]ethyl]-7-methyl-
6-[2-[4-[Bis(4-fluorophenyl)Methylidene]piperidin-1-yl]ethyl]-7-Methyl-[1,3]thiazolo[2,3-b]pyriMidin-5-one HCl | [Molecular Formula]
C27H25F2N3OS | [MDL Number]
MFCD00069341 | [MOL File]
87051-43-2.mol | [Molecular Weight]
477.57 |
| Chemical Properties | Back Directory | [Melting point ]
145.5° | [Boiling point ]
618.7±65.0 °C(Predicted) | [density ]
1.30±0.1 g/cm3(Predicted) | [storage temp. ]
Store at +4°C | [solubility ]
methanol: >10 mg/mL
| [form ]
solid
| [pka]
7.74±0.20(Predicted) | [color ]
white
|
| Hazard Information | Back Directory | [Uses]
A potent 5-HT2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier.
| [Definition]
ChEBI: A thiazolopyrimidine that is 5H-[1,3]thiazolo[3,2-a]pyrimidin-5-one which is substituted at position 7 by a methyl group and at position 6 by a 2-{4-[bis(4-fluorophenyl)methylidene]piperidin-1-yl}ethyl group. A potent and lo
g-acting seratonin (5-hydroxytryptamine, 5-HT) antagonist of the subtype 5-HT2 (Ki = 0.39 nM), it is used in the treatment of a variety of disorders including anxiety, depression and schizophrenia. It has little sedative action. | [Brand name]
Tiserton (Janssen). | [Hazard]
A poison.
| [Biological Activity]
Potent and long-acting 5-HT 2 receptor antagonist (K i = 0.39 nM). Anxiolytic in vivo . | [Description]
Ritanserin, also known by its developmental code name R-55667, is a serotonin antagonist medication described as an anxiolytic, antidepressant, antiparkinsonian agent, and antihypertensive agent. It was never marketed for medical use due to safety problems but has been used in scientific research to study the serotonin system. | [Biochem/physiol Actions]
Potent 5-HT2A serotonin receptor antagonist/inverse agonist that crosses the blood-brain barrier. | [storage]
Store at +4°C |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
36/37/38 | [Safety Statements ]
22-26-36 | [WGK Germany ]
3
| [Toxicity]
LD50 in male, female mice, rats, dogs (mg/kg): 28.2, 28.2, 20.0, 22.2, 24.1, 33.2 i.v.; 626, 993, 956, 515, ~1280, 640-1280 orally (Awouters) |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
|