| Identification | Back Directory | [Name]
ML-180 | [CAS]
863588-32-3 | [Synonyms]
SR1848
ML-180
ML-180 (SR1848)
SR1848 >=98% (HPLC)
6-[4-(3-chlorophenyl)piperazin-1-yl]-3-cyclohexyl-1H-pyrimidine-2,4-dione
6-(4-(3-chlorophenyl)piperazin-1-yl)-3-cyclohexylpyrimidine-2,4(1H,3H)-dione
2,4(1H,3H)-Pyrimidinedione, 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl- | [Molecular Formula]
C20H25ClN4O2 | [MDL Number]
MFCD05894342 | [MOL File]
863588-32-3.mol | [Molecular Weight]
388.89 |
| Chemical Properties | Back Directory | [density ]
1.312±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMSO: 10 mg/ml | [form ]
A crystalline solid | [pka]
9.37±0.40(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Description]
ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1, IC50 = 3.7 μM) with maximum efficacy of 64% repression.1 It is inactive at the related steroidogenic factor-1 transcriptional activator.1 Through LRH-1, ML-180 alters the expression of haptoglobin and serum amyloid proteins A1 and A4, induces the death of estrogen-receptor negative MDA-MB-231 breast cancer cells, and inhibits the steroidogenic acute regulatory promoter (IC50 = 2.05 μM).1 | [Definition]
ChEBI: 6-[4-(3-chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione is a member of piperazines. |
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DC Chemicals
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