| Identification | Back Directory | [Name]
ML364 | [CAS]
1991986-30-1 | [Synonyms]
ML364
ML364, >98%
ML 364;ML-364
ML364 >=98% (HPLC)
ML364, 1991986-30-1
Benzamide, 2-[[(4-methylphenyl)sulfonyl]amino]-N-(4-phenyl-2-thiazolyl)-4-(trifluoromethyl)- | [Molecular Formula]
C24H18F3N3O3S2 | [MDL Number]
MFCD30718174 | [MOL File]
1991986-30-1.mol | [Molecular Weight]
517.54 |
| Chemical Properties | Back Directory | [density ]
1.457±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Store in freezer, under -20°C | [solubility ]
DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml; Ethanol: 20 mg/ml | [form ]
A crystalline solid | [pka]
6.51±0.50(Predicted) | [color ]
Light yellow to yellow |
| Hazard Information | Back Directory | [Uses]
ML364 is a small molecular inhibitor of the deubiquitinase USP2, which accelerates cyclin D1 degrdation and leads to cell cycle arrest in colorectal cancer and mantle cell lymphoma. | [Biological Activity]
ML364 is a potent and specific inhibitor of the deubiquitinase USP2 th at induces cellular Cyclin D1 degradation in HCT116 colorectal cancer cellsfollowed by cell cycle arrest and apoptosis. AlsoML364 inhibits homologous recombination (HR)-mediated DNA repair. | [storage]
Store at -20°C |
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