| Identification | More | [Name]
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride | [CAS]
84484-78-6 | [Synonyms]
1-[1-(4-CHLOROPHENYL)CYCLOBUTYL]-3-METHYLBUTYLAMINE HCL
1-[1-(4-Chlorophenyl)cyclobutyl]-3-methylbutylamine hydrochloride
1-(4-CHLOROPHENYL)-BETA-(2-METHYLPROPYL)CYCLOBUTANEMETHANAMINE HYDROCHLORIDE
BTS 54-505
N-DI-DESMETHYL SIBUTRAMINE HCL
N-DI-DESMETHYL SIBUTRAMINE HYDROCHLORIDE
1-(4-Chlorophenyl)-alpha-(2-Methylpropyl)Cyclobutane Methanamine Hydrochloride
1-[1-(4-Chlorophenyl)-alpha-(2-methylpropyl)cyclbutanemethan amine hydrochloride
Cyclobutamethamine,1-(4-chlorophenyl)-alpha-(2-methylpropyl)HCl
N-[1-(4-chlorophenyl)cyclobutyl-3-methylbutyl)]hydrochloride
Cyclobutanemethanamine, 1-(4-chlorophenyl)-α-(2-methylpropyl)-, ochloride
CYCLOBUTANEMETHANAMINE, 1-(4-CHLOROPHENYL)-A-(2-METHYLPROPYL)-, OCHLORIDE | [Molecular Formula]
C15H23Cl2N | [MDL Number]
MFCD03411585 | [Molecular Weight]
288.26 | [MOL File]
84484-78-6.mol |
| Hazard Information | Back Directory | [Uses]
A metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure. | [Uses]
A metabolite of Sibutramine, a serotonin and noradrenaline reuptake inhibitor (SNR). Decreases calorie intake and increases energy expenditure. | [Biological Activity]
Potently active primary amine metabolite of sibutramine (1-(4-Chlorophenyl)-N,N-dimethyl-a-(2-methylpropyl)cyclobutanemethanamine hydrochloride ) that exhibits a similar pharmacological profile to the parent compound. Inhibits serotonin and noradrenalin reuptake more potently than sibutramine in vitro . In vivo, reduces food intake in rodents following i.c.v. administration and increases energy expenditure via thermogenesis. | [in vitro]
simultaneous application of bts 54-505 with 5-ht resulted in a prolongation of the recovery time from the 5-ht-mediated suppression of discharge activity. bts 54-505 also prolonged the recovery time from a na-mediated potentiation of firing. these effects on recovery time are attributed to the inhibition of uptake of both 5-ht and na by bts 54-505. the amplitude of the response to 5-ht or na was unaffected by co-ejection of bts 54-505 [1]. | [in vivo]
the secondary (bts 54-354) and primary (bts 54-505) amine metabolites of sibutramine hcl exhibit similar in vivo pharmacological activity to the parent compound. thus, each compound displays potent activity in acute behavioural models predictive of antidepressant effects and a comparable ability to inhibit the uptake of monoamines [2]. | [IC 50]
0.066 μm for noradrenaline uptake; 5.1 μm for 5-ht uptake; 0.31 μm for dopamine uptake | [storage]
Desiccate at RT | [References]
[1] scott g, luscombe gp, mason r. the effects of bts 54-505, a metabolite of sibutramine, on monoamine and excitatory amino acid-evoked responses in the rat dorsolateral geniculate nucleus in vivo. br j pharmacol. 1994 jan;111(1):97-102.
[2] luscombe gp, hopcroft rh, thomas pc, buckett wr. the contribution of metabolites to the rapid and potent down-regulation of rat cortical beta-adrenoceptors by the putative antidepressant sibutramine hydrochloride. neuropharmacology. 1989 feb;28(2):129-34. |
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