| Identification | Back Directory | [Name]
TOLRESTAT | [CAS]
82964-04-3 | [Synonyms]
CS-148
Alredase
AY-27773
Lorestat
TOLRESTAT
Aldredase
Tolrestatin
TOLRESTAT USP/EP/BP
Tolrestat, AY 27773
TOLRESTAT(FORR&DONLY)
AY-27773;AY 27773; AY27773
TolrestattolrestattolrestatTolrestat
N-[[6-Methoxy-5-(trifluoromethyl)naphthalen-1-yl]thioxomethyl]-N-methylglycine
N-[[6-Methoxy-5-(triiquoromethyl)-1-naphthalenyl]thioxomethyl]-N-methylglyeine
2-(6-Methoxy-N-Methyl-5-(trifluoroMethyl)naphthalene-1-carbothioaMido)acetic acid
Glycine, N-[[6-methoxy-5-(trifluoromethyl)-1-naphthalenyl]thioxomethyl]-N-methyl-
[(6-Methoxy-5-trifluoromethyl-naphthalene-1-carbothioyl)-methyl-amino]-acetic acid | [Molecular Formula]
C16H14F3NO3S | [MDL Number]
MFCD00864170 | [MOL File]
82964-04-3.mol | [Molecular Weight]
357.35 |
| Chemical Properties | Back Directory | [Melting point ]
164-165° | [Boiling point ]
498.1±55.0 °C(Predicted) | [density ]
1.399±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly) | [form ]
powder | [pka]
3.49±0.10(Predicted) | [color ]
white to beige | [CAS DataBase Reference]
82964-04-3 |
| Hazard Information | Back Directory | [Description]
Tolrestat is a long-acting aldose reductase inhibitor reportedly useful in the prophylaxis of diabetic neuropathy, retinopathy and cataracts. | [Originator]
American Home Products (USA) | [Uses]
Alredase
(Wyeth-Ayerst). | [Definition]
ChEBI: Tolrestat is a member of naphthalenes. It has a role as an EC 1.1.1.21 (aldehyde reductase) inhibitor. | [Brand name]
Alredase | [Biochem/physiol Actions]
Tolrestat is considered to be effective in treating the consequences of diabetes including neuropathy, nephropathy, retinopathy and esophageal motility and vibration perception. Tolrestat is also believed to have lesser or no toxic effects. |
|
| Company Name: |
LGM Pharma
|
| Tel: |
1-(800)-881-8210 |
| Website: |
www.lgmpharma.com |
|