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ChemicalBook--->CAS DataBase List--->825658-06-8

825658-06-8

825658-06-8 Structure

825658-06-8 Structure
IdentificationBack Directory
[Name]

ML335
[CAS]

825658-06-8
[Synonyms]

TREK-1/2 Activator
ML335; ML-335; ML 335; TREK-1/2 ACTIVATOR
Benzamide, N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-
[Molecular Formula]

C15H14Cl2N2O3S
[MDL Number]

MFCD06003481
[MOL File]

825658-06-8.mol
[Molecular Weight]

373.25
Chemical PropertiesBack Directory
[storage temp. ]

-20°
[solubility ]

Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
[form ]

solid
[color ]

White
[Stability:]

Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety DataBack Directory
[Symbol(GHS) ]


GHS07
[Signal word ]

Warning
[Hazard statements ]

H319-H315-H335
[Precautionary statements ]

P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard InformationBack Directory
[Description]

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels.
[Uses]

ML335, is a selective activator of both TREK-1 and TREK-2.
[storage]

Store at +4°C
[References]

1) Lolicato?et al.?(2017),?K2P2.1 (TREK-1)-activator complexes reveal a cryptic selectivity filter binding site; Nature,?547?364
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