| Identification | More | [Name]
Eucalyptus oil | [CAS]
8000-48-4 | [Synonyms]
EUCALYPTUS CITRIODORA OIL
EUCALYPTUS OIL
EUCALYPTUS OIL CITRIODORA
FEMA 2466
OIL OF EUCALYPTUS
OIL OF EUCALYPTUS CITRIODORA
SAUNA/STEAM EUCALYPTUS
dinkumoil
eucalvptusoil
eucalyptus
eukalyptusoel
Oils,eucalyptus
EUCALYPTUS OIL 80
EUCALYPTUS GLOBULUS LEAF OIL
EUCALYPTUS OIL 70/75% FCC
EUCALYPTUS OIL 80/85%
ingalipt
OLEUMEUCALYPTI
1,3,3-Trimethyl-2-oxabicyclo[2.2.2.]-octane
OIL OF EUCALYPTUS D ~0.91 | [EINECS(EC#)]
283-406-2 | [Molecular Formula]
C10H18O | [MDL Number]
MFCD00146880 | [Molecular Weight]
154.25 | [MOL File]
8000-48-4.mol |
| Chemical Properties | Back Directory | [Boiling point ]
200 °C
| [density ]
0.909 g/mL at 25 °C
| [FEMA ]
2466 | [refractive index ]
n20/D 1.46
| [Fp ]
135 °F
| [form ]
Liquid | [color ]
Colourless to pale yellow | [Odor]
at 100.00 %. eucalyptus | [Odor Type]
herbal | [Dielectric constant]
4.8399999999999999 | [InChI]
InChI=1S/C10H18O/c1-9(2)8-4-6-10(3,11-9)7-5-8/h8H,4-7H2,1-3H3 | [InChIKey]
WEEGYLXZBRQIMU-UHFFFAOYSA-N | [SMILES]
C12(C)CCC(CC1)C(C)(C)O2 | [Uses]
eucalyptus oil is described as having antiseptic, disinfectant, antifungal, and blood-circulation activating properties. It is also used as a fragrance. native to Australia, it was regarded as a general cure-all by the Aborigines and later by the european settlers. It has a long tradition of use in medicine, and is considered one of the most powerful and versatile herbal remedies. It is said that eucalyptus oil’s anti-septic properties and disinfectant action increase as the oil ages. The most important constituent of the oil is eucalyptol. The essential oil is obtained from eucalyptus leaves. eucalyptus oil may cause allergic reactions. | [CAS DataBase Reference]
8000-48-4(CAS DataBase Reference) | [EPA Substance Registry System]
8000-48-4(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R10:Flammable.
R38:Irritating to the skin. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
2
| [RTECS ]
LE2530000
| [HazardClass ]
3.2 | [PackingGroup ]
III | [HS Code ]
33012960 | [Safety Profile]
A human poison by
ingestion. Moderately toxic by skin contact.
Human systemic effects by ingestion: cihary
eye spasms, nausea or vomiting, respiratory
depression, somnolence, sweating. A skin
irritant. When heated to decomposition it
emits acrid smoke and irritating fumes. See
also ALDEHYDES. | [Toxicity]
The acute oral LD50 value of eucalyptol was reported as 2480 mg/kg in the rat (Jenner, Hagan, Taylor, Cook & Fitzhugh, 1964). The acute dermal LD50 in rabbits exceeded 5 g/kg (Moreno, 1973). |
| Hazard Information | Back Directory | [Description]
Eucalyptus oil is the generic name for distilled oil from the leaf of Eucalyptus, a genus of the plant family Myrtaceae native to Australia and cultivated worldwide. Eucalyptus oil has a history of wide application, as a pharmaceutical, antiseptic, repellent, flavoring, fragrance and industrial uses. The leaves of selected Eucalyptus species are steam distilled to extract eucalyptus oil.
| [Chemical Properties]
E. globulus oil is produced by steam distillation of the leaves of E. globulus
Labill. It is an almost colorless to pale yellow liquid with a fresh odor,
characteristic of cineole.Thecrude oil contains more than 60% 1,8-cineole
and between 10% and 22% α-pinene. Rectified qualities have
a cineole content of more than 70 % or more than 80%. The respective
specifications of these three types are as follows:
d2020 0.905–0.925/0.904–0.920/0.906–0.920; n20D 1.457–1.475/1.460–1.468/1.458–1.465; α20D +2 ° to +8 °/0 ° to +10 °/+2 ° to +10 °; solubility:
1 vol in max. 7/10/5 vol 70% ethanol. 1.8-cineole content 60/70/80% minimum.
Worldwide production of cineole-containing eucalyptus oils is ～4000 t/
yr. Previously, the oil was distilled mainly in Spain and Portugal; today, it
is produced mainly in China (～3000 t/yr), smaller quantities from India and South Africa.
Eucalyptus oils with high cineole content are used for cineole production.
The oils and cineole itself are used primarily in pharmaceutical
preparations. Fairly large quantities are also used in perfumery, for
example, to imitate the odor of cineole-containing essential oils and
flavoring of food (sweets) and oral care products. | [Chemical Properties]
The oil is obtained by steam distillation of the fresh or partly dried long and narrow leaves in approximately 1% yields.
It has a characteristic aromatic, somewhat camphoraceous odor and a pungent, spicy, cooling taste. The oil extracted has medicinal
and aromatic uses. | [Chemical Properties]
Tree native to Australia, cultivated in temperate regions. It has opposite, lanceolated leaves and white or pinkish flowers. The part used is the leaves of the mature tree. Eucalyptus has a tonic astringent flavor. | [Occurrence]
Found in the leaves of Eucalyptus globulus Labill. and other species of Euca lyptus L'Héritier (Fam: Myrtaceae) (Guenther, 1950). | [History]
Australian Aboriginals use eucalyptus leaf infusions ( which contain eucalyptus oil ) as a traditional medicine for treating body pains, sinus congestion, fever, and colds.
Baron Ferdinand von Mueller, Victorian botanist, promoted the qualities of Eucalyptus as a disinfectant in "fever districts", and also encouraged Joseph Bosisto, a Melbourne pharmacist, to investigate the commercial potential of the oil . Bosisto started the commercial eucalyptus oil industry in 1852 near Dandenong, Victoria, Australia, when he set up a distillation plant and extracted the essential oil from the cineole chemo type of Eucalyptus radiata. This resulted in the cineole chemo type becoming the generic 'oil of eucalyptus', and "Bosisto's Eucalyptus Oil" still survives as a brand.
The Australian eucalyptus oil industry peaked in the 1940s, the main area of production being the central goldfields region of Victoria, particularly Inglewood; then the global establishment of eucalyptus plantations for timber resulted in increased volumes of eucalyptus oil as a plantation by-product.
By the 1950s the cost of producing eucalyptus oil in Australia had increased so much that it could not compete against cheaper Spanish and Portuguese oils (closer to European Market there fore less costs). Non-Australian sources now dominate commercial eucalyptus oil supply, although Australia continues to produce high grade oils, mainly from blue mallee (E. polybractea) stands. | [Definition]
Extractives and their physically modified derivatives. Eucalyptus, Myrtaceae. | [Preparation]
By steam distillation of the leaves of E. globulus Labill. and other species of Eucalyptus L'Heritier (Gildemeister & Hoffman, 1961 ; Guenther, 1950). | [Production Methods]
Eucalyptus oils in the trade are categorized into three broad types according to their composition and main end-use: medicinal, perfumery and industrial . The most prevalent is the standard cineolebased "oil of eucalyptus", a colourless mobile liquid (yellow with age) with a penetrating, camphoraceous, woody-sweet scent.
China produces about 75 % of the world trade, but most of this is derived from camphor oil fractions rather than being true eucalyptus oil . . | [Essential oil composition]
Some of the chemicals isolated and detected on the basis of UV, mass, and NMR spectroscopic analyses
from the stem bark are pinoresinol, vomifoliol, 3,4,5-trimethoxyphenol 1-O-beta-D-(6?-O-galloyl)glucopyranoside, methyl gallate,
rhamnazin, rhamnetin, eriodictyol, quercetin, taxifolin, engelitin, and catechin.* An unusual heteroxylan composed of galactosyl,
4-O-methyl-glucuronosyl and xylosyl residues with molar ratio 1:3:30 was isolated from the wood of E. globulus Labill.? The flower
(bud) oil contains terpenic hydrocarbons (α-thujene 11.95%, limonene 3.1%, aromadendrene 16.57%) and oxygenated compounds
(1,8-cineole 36.95%) (CoE, 2000). | [Essential oil composition]
The leaves essential oil mainly contains terpenic hydrocarbons and oxygenated terpenic compounds
(1–8-cineole 62.4 to 82.2%). In addition to cineol (eucalyptol), it also contains terpineol, sesquiterpene alcohols, various aliphatic
aldehydes, isoamyl alcohol, ehtanol and terpenes. | [Taste threshold values]
FEMA PADI: n/a IOFI: n/a | [Safety]
If consumed internally at low dosage as a flavoring component or in pharmaceutical products at the recommended rate, cineole-based 'oil of eucalyptus' is safe for adults. However, systemic toxicity can result from ingestion or topical application at higher than recommended doses.
The probable lethal dose of pure eucalyptus oil for an adult is in the range of 0.05 mL to 0.5 mL / per kg of body weight . Because of their high body surface area to mass ratio, children are more vulnerable to poisons absorbed trans dermally. Severe poisoning has occurred in children after ingestion of 4 mL to 5 mL of eucalyptus oil. | [Metabolism]
1,8-Cineole (eucalyptol), the chief constituent of eucalyptus oil, apparently undergoes oxidation in vivo with the formation of hydroxycineole which is excreted as hyd roxycineoleglucuronic acid (Williams, 1959). |
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