| Identification | More | [Name]
Difluoroethane | [CAS]
75-37-6 | [Synonyms]
1,1-DIFLUOROETHANE
DIFLUOROETHANE
ETHYLIDENE DIFLUORIDE
ETHYLIDENE FLUORIDE
FC-152A
freon 152a
HFC-152A
1,1-Difluorethan
1,1-difluoro-ethan
Algofrene Type 67
Algofrene67
algofrenetype67
CH3CHF2
Dymel 152
dymel152
dymel152a
ethane,1,1-difluoro-
ethylenefluoride
F152A
FKW152a | [EINECS(EC#)]
200-866-1 | [Molecular Formula]
C2H4F2 | [MDL Number]
MFCD00000449 | [Molecular Weight]
66.05 | [MOL File]
75-37-6.mol |
| Safety Data | Back Directory | [Hazard Codes ]
F | [Risk Statements ]
R11:Highly Flammable. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S33:Take precautionary measures against static discharges .
S36:Wear suitable protective clothing .
S38:In case of insufficient ventilation, wear suitable respiratory equipment . | [RIDADR ]
UN 1030 2.1
| [WGK Germany ]
1
| [RTECS ]
KI1410000
| [Hazard Note ]
Flammable | [DOT Classification]
2.1 (Flammable gas) | [HazardClass ]
2.1 | [HS Code ]
2903392500 | [Safety Profile]
Mildly toxic by
inhalation. Mutation data reported. Narcotic
in high concentration. A very dangerous fire
hazard when exposed to heat or flame; can
react vigorously with oxidzing materials. See
also FLUORIDES. | [Hazardous Substances Data]
75-37-6(Hazardous Substances Data) | [Toxicity]
LC50 inhalation in mouse: 977gm/m3/2H |
| Hazard Information | Back Directory | [General Description]
1,1-DIFLUOROETHANE(75-37-6) is colorless, odorless gas shipped as a liquefied gas under its vapor pressure. Contact with the liquid can cause frostbite. 1,1-DIFLUOROETHANE(75-37-6) is easily ignited. Its vapors are heavier than air and a flame can travel back to the source of leak very easily. This leak can be either a liquid or vapor leak. 1,1-DIFLUOROETHANE(75-37-6) can asphyxiate by the displacement of air. Under prolonged exposure to fire or heat the containers may rupture violently and rocket. | [Reactivity Profile]
Halogenated aliphatic compounds, such as 1,1-DIFLUOROETHANE, are moderately or very reactive. Reactivity generally decreases with increased degree of substitution of halogen for hydrogen atoms. Low molecular weight haloalkanes are highly flammable and can react with some metals to form dangerous products. Materials in this group are incompatible with strong oxidizing and reducing agents. Also, they are incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides. The reaction of aluminum with various halogenated hydrocarbons produces a self-sustaining reaction with sufficient heat to melt aluminum pieces, examples of other halogenated hydrocarbons are fluorotrichloromethane, dichlorodifluoromethane, chlorodifluoromethane, tetrafluoromethane. The vigor of the reaction appears to be dependent on the combined degree of fluorination and the vapor pressure, [Chem. Eng. News 39(27):44(1961)]. | [Air & Water Reactions]
Highly flammable. | [Health Hazard]
Inhalation of concentrated gas will cause suffocation. Contact with liquid can damage eyes because of low temperature. Frostbite may result from contact with liquid. | [Chemical Properties]
Difluoroethane is a liquefied gas and exists as a liquid at room temperature when contained under its own vapor pressure, or as a gas when exposed to room temperature and atmospheric pressure. The liquid is practically odorless and colorless. Difluoroethane is noncorrosive and nonirritating. | [Chemical Properties]
liquefied colourless gas under pressure | [Uses]
HFC 152a is a specialty liquified hydrofluorocarbon gas. It is
used as an intermediate in the production of fluorinated polymers,
as an aerosol propellant in some specialty applications,
and as a component in some refrigerant blends. | [Production Methods]
Difluoroethane is prepared from ethyne by the addition of hydrogen fluoride in the presence of a suitable catalyst. The difluoroethane formed is purified to remove all traces of water, as well as traces of the starting materials.
| [Pharmaceutical Applications]
Difluoroethane, a hydrofluorocarbon (HFC), is an aerosol propellant used in topical pharmaceutical formulations. Difluoroethane may be used as a vehicle for dispersions and emulsions.
Since difluoroethane does not contain chlorine, there are no environmental controls on the use of this material as a propellant, since it does not deplete the ozone layer and is not a greenhouse gas.
| [Safety]
Difluoroethane may be used as an aerosol propellant in topical pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritant material.
Deliberate inhalation of excessive quantities of this propellant may result in death, and the following ‘warning’ statements must appear on the label of all aerosols:
WARNING: Avoid inhalation. Keep away from eyes or other mucous membranes.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Do not inhale directly; deliberate inhalation of contents can cause death.or
WARNING: Use only as directed; intentional misuse by deliberately concentrating and inhaling the contents can be harmful or fatal.
WARNING: Contents under pressure. Do not puncture or incinerate container. Do not expose to heat or store at room temperature above 120°F (49°C). Keep out of the reach of children.
When propellants are used in topical aerosols they may cause a chilling effect on the skin, although this effect has been somewhat overcome by the use of vapor-tap valves. The propellants quickly vaporizefromtheskin,andarenonirritating whenusedasdirected. | [storage]
Difluoroethane is a nonreactive and stable material. The liquefied gas is stable when used as a propellant and should be stored in a metal cylinder in a cool, dry place. | [Incompatibilities]
Compatible with the usual ingredients used in the formulation of pharmaceutical aerosols. | [Regulatory Status]
Accepted in the USA, by the FDA, for use as a topical aerosol propellant. |
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