| Identification | More | [Name]
1-Methyl-3-nitro-1-nitrosoguanidine | [CAS]
70-25-7 | [Synonyms]
1-METHYL-3-NITRO-1-NITROSOGUANIDINE
DIAZOMETHANE PRECURSOR
MNNG
N-METHYL-N'-NITRO-N-NITROSOGUANIDINE
N-METHYL-N-NITROSO-N'-NITROGUANIDINE
1-Methyl-1-Nitroso-3-nitroguanidine
1-methyl-3-nitro-1-nitroso-guanidin
1-nitroso-3-nitro-1-methylguanidine
Guanidine, 1-methyl-3-nitro-1-nitroso-
Methylnitronitrosoguanidine
MNG
mnng(n-methyl-n’-nitro-n-nitrosoguanidine
n’-nitro-n-nitroso-n-methylguanidine
NA 1325
nci-c01423
N-Methyl-N',2-dioxohydrazinecarboximidohydrazide 2-oxide
n-methyl-n’-nitro-n-nitroso-guanidin
N-Methyl-N-nitrosonitroguanidin
n-methylo-n’-nitro-n-nitrozoguanidyny(polish)
n-metylo-n’-nitro-n-nitrozoguanidyny | [EINECS(EC#)]
200-730-1 | [Molecular Formula]
C2H5N5O3 | [MDL Number]
MFCD00007034 | [Molecular Weight]
147.09 | [MOL File]
70-25-7.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow to pink crystals | [Melting point ]
118°C (dec.) | [Boiling point ]
267.16°C (rough estimate) | [density ]
1.7979 (rough estimate) | [refractive index ]
1.6410 (estimate) | [storage temp. ]
0-6°C
| [solubility ]
almost transparency in hot Methanol | [form ]
powder to crystal | [pka]
3.09±0.50(Predicted) | [color ]
Light yellow to Brown | [Stability:]
Unstable. Reacts violently with water. May detonate under impact. Heat, light and moisture sensitive. May explode if stored in sealed ampules. Highly flammable. Incompatible with aqueous solutions, acids, bases, oxidizing agents, reducing agents. Alkaline hydrolysis releases toxic and explosive gases. | [Water Solubility ]
Reacts violently | [Merck ]
6103 | [InChIKey]
VZUNGTLZRAYYDE-UHFFFAOYSA-N | [CAS DataBase Reference]
70-25-7(CAS DataBase Reference) | [IARC]
2A (Vol. 4, Sup 7) 1987 | [NIST Chemistry Reference]
Guanidine, n-methyl-n'-nitro-n-nitroso-(70-25-7) | [Storage Precautions]
Light sensitive | [EPA Substance Registry System]
70-25-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
T;N,N,T | [Risk Statements ]
R45:May cause cancer.
R20:Harmful by inhalation.
R36/38:Irritating to eyes and skin .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
2926 | [RTECS ]
MF4200000 | [HS Code ]
2925.29.9000 | [HazardClass ]
4.1 | [PackingGroup ]
II | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
tumorigenic, and teratogenic data. Poison by
ingestion, intraperitoneal, and intravenous
routes. Moderately toxic by subcutaneous
route. Experimental reproductive effects.
Human mutation data reported. An
explosive sensitive to heat or impact.
Flammable when exposed to heat or flame;
can react vigorously with oxidizing
materials. When heated to decomposition it
emits very toxic fumes of NOx. | [Hazardous Substances Data]
70-25-7(Hazardous Substances Data) | [Toxicity]
LD50 oral in rat: 90mg/kg |
| Hazard Information | Back Directory | [General Description]
A yellow powder. Melting point 244°F. Decomposes above 212°F. A suspected carcinogen. Extremely hazardous as a mutagen. Avoid skin contact and inhalation of of vapors. Usually stored frozen (below 32°F) in polyethylene bottles that are tightly closed and contained in a metal can. May decomposed during prolonged storage and develop sufficient pressure in a closed container to explode. Keep away from heat, sparks, and open flame. | [Reactivity Profile]
N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(70-25-7) will detonate under high impact. N-METHYL-N'-NITRO-N-NITROSOGUANIDINE(70-25-7) is sensitive to heat. A sample has exploded when melted in a sealed capillary tube. Incompatible with acids, bases, oxidizing agents and reducing agents. Reacts with bases to release highly toxic, irritating and explosive gases. Reacts slowly with acids to release nitrous acid. Reacts with various nucleophiles, especially amines and thiols. Reacts with aqueous potassium hydroxide to form a highly reactive compound. The crude product from aqueous nitrosation is pyrophoric but recrystallized material is stable . | [Air & Water Reactions]
Highly flammable. Reacts violently with water . | [Health Hazard]
Fire may produce irritating and/or toxic gases. Contact may cause burns to skin and eyes. Contact with molten substance may cause severe burns to skin and eyes. Runoff from fire control may cause pollution. | [Fire Hazard]
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished. | [Chemical Properties]
yellow to pink crystals | [Uses]
A DNA-damaging agent, used as a positive control in SHE cell transformation assays. | [Uses]
Experimentally as carcinogen and mutagen. Formerly in preparation of diazomethane. | [Definition]
ChEBI: An N-nitroguanidine compound having nitroso and methyl substituents at the N'-position | [Production Methods]
MNNG is one of the first chemical mutagens and is a
stabilized form of methylnitrosoguanidine, which has not
been isolated. It does not occur in nature, and human exposure
to it is limited to laboratories. | [Carcinogenicity]
N-Methyl-N-nitro-N-nitrosoguanidine (MNNG) is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | [storage]
Store at -20°C,unstable in solution, ready to use. |
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