| Identification | More | [Name]
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE | [CAS]
69304-37-6 | [Synonyms]
1,1,3,3-TETRAISOPROPYL-1,3-DICHLORODISILOXANE
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-1,3-DISILOXANE
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE
1,3-DICHLOROTETRAISOPROPYLDISILOXANE
1,3-DICHLOROTETRAISOPROPYLSILOXANE
TIPDSICL2
TIPSCL
1,1,3,3-Tetraisopropyl-1,3-dichlorosiloxane
chloro-(chloro-dipropan-2-yl-silyl)oxy-dipropan-2-yl-silane
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYL-
Disiloxane, 1,3-dichloro-1,1,3,3-tetrakis(1-methylethyl)-
1,3-Dichloro-1,1,3,3-tetraisopropoxydisiloxane
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent]
1,1,3,3-Tetraisopropyl-1,3-dichloropropanedisiloxane
1,3-Dichloro-1,1,3,3-tetraisopropylpropanedisiloxane
2,6-Dimethyl-3,5-dichloro-3,5-diisopropyl-4-oxa-3,5-disilaheptane
Bis(chlorodiisopropylsilyl) ether | [EINECS(EC#)]
629-558-9 | [Molecular Formula]
C12H28Cl2OSi2 | [MDL Number]
MFCD00009655 | [Molecular Weight]
315.43 | [MOL File]
69304-37-6.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless liquid | [Boiling point ]
70 °C0.5 mm Hg(lit.)
| [density ]
0.986 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.454(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
Miscible with dimethylformamide, hexane, ethyl acetate, chloroform and dichloromethane. | [form ]
Oil | [color ]
Colourless | [Specific Gravity]
0.986 | [Hydrolytic Sensitivity]
8: reacts rapidly with moisture, water, protic solvents | [Sensitive ]
Moisture Sensitive | [BRN ]
1934216 | [InChI]
InChI=1S/C12H28Cl2OSi2/c1-9(2)16(13,10(3)4)15-17(14,11(5)6)12(7)8/h9-12H,1-8H3 | [InChIKey]
DDYAZDRFUVZBMM-UHFFFAOYSA-N | [SMILES]
[Si](Cl)(C(C)C)(C(C)C)O[Si](Cl)(C(C)C)C(C)C | [CAS DataBase Reference]
69304-37-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
UN 3265 8/PG 2
| [WGK Germany ]
3
| [F ]
10-21 | [Hazard Note ]
Corrosive | [TSCA ]
No | [HazardClass ]
8 | [PackingGroup ]
II | [HS Code ]
29319090 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless liquid | [Physical properties]
bp 70°C/0.5 mmHg; d 0.986 g cm?3. | [Uses]
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane can be used as simultaneous protection of the 3'- and 5'-hydroxyl functions of
furanose nucleosides;protecting group for carbohydrates;3,4
protecting group reagent for open-chain polyhydroxy compounds;
preparation of cyclic bridged peptides.
The reagent
design was based upon the fact that triisopropylsilyl chloride
reacts 1000 times faster with primary alcohols than secondary
alcohols. Thus in the case of 3',5'-dihydroxy nucleosides the
reagent initially silylates at the 5'-position. This is then followed
by intramolecular reaction with the secondary alcohol at the
3'-position to give the doubly protected derivative (eq 1).
| [Uses]
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane is used in the analysis of Watson-Crick and Hoogstein base pairing in nucleotides. Also used in the formation of ribavirin chemical delivery systems. | [Preparation]
can be prepared starting from trichlorosilane
by treatment with i-PrMgCl, H2O, and acetyl chloride.
Alternatively, it can be prepared by the reaction of 1,1,3,3-
tetraisopropyldisiloxane with CCl4 in the presence of catalytic
PdCl2.This method is also suitable for its in situ preparation. |
| Spectrum Detail | Back Directory | [Spectrum Detail]
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)1HNMR
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)IR
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)Raman
1,3-DICHLORO-1,1,3,3-TETRAISOPROPYLDISILOXANE(69304-37-6)FT-IR
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| Well-known Reagent Company Product Information | Back Directory | [Acros Organics]
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 96%(69304-37-6) | [Alfa Aesar]
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane, 97%(69304-37-6) | [Sigma Aldrich]
69304-37-6(sigmaaldrich) | [TCI AMERICA]
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane [Hydroxyl Protecting Agent],>97.0%(GC)(69304-37-6) |
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