| Identification | More | [Name]
3-Hydroxypiperidine | [CAS]
6859-99-0 | [Synonyms]
3-HYDROXYPIPERIDINE
3-PIPERIDINOL
PIPERIDIN-3-OL
3-Hydroxypiperadine
3-HYDROXYPIPERIDINE 98%
3-Hydroxypiperidine/3-Piperidinol | [EINECS(EC#)]
229-957-4 | [Molecular Formula]
C5H11NO | [MDL Number]
MFCD00014591 | [Molecular Weight]
101.15 | [MOL File]
6859-99-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White to light yellow crystalline powder and lumps | [Melting point ]
57-61 °C | [Boiling point ]
67-69 °C (2 mmHg)
| [density ]
1.016±0.06 g/cm3(Predicted) | [Fp ]
>100°C | [storage temp. ]
2-8°C
| [solubility ]
ethanol: 0.1 g/mL, clear
| [form ]
Crystalline Powder and Lumps | [pka]
14.91±0.20(Predicted) | [color ]
White to light yellow | [PH]
11.5-11.7 (H2O)Aqueous solution | [Water Solubility ]
soluble | [Sensitive ]
Air Sensitive & Hygroscopic | [BRN ]
102696 | [InChIKey]
BIWOSRSKDCZIFM-UHFFFAOYSA-N | [LogP]
-0.35 | [CAS DataBase Reference]
6859-99-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
C,Xi | [Risk Statements ]
R34:Causes burns.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S27:Take off immediately all contaminated clothing . | [RIDADR ]
UN 3263 8/PG 2
| [WGK Germany ]
3
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29333990 |
| Questions And Answer | Back Directory | [Background]
Many piperidine derivatives have multiple pharmacological activities such as antibacterial, antitumor, treatment of Alzheimer's disease and anesthesia. They are also important drugs for the treatment of viral infections (including AIDS) and diabetes. 3-Hydroxypiperidine or its derivatives are one of the important intermediates, which are widely used in the synthesis of drug intermediates such as chiral 3-aminopiperidine. It is of great significance to develop a synthesis method suitable for industrial production. |
| Hazard Information | Back Directory | [Chemical Properties]
White to light yellow crystalline powder and lumps | [Application]
3-Hydroxypiperidine may be used to synthesize the following:
2-pyrrolidinone via oxidation with iodosylbenzene
1-[2,8-bis(trifluoromethyl)quinolin-4-yl]piperidin-3-ol via reaction with 4-bromoquinoline
Reactant for:
Synthesis of unsymmetrical ureas
Synthesis of piperidine nucleoside analogs
Fluorination reactions
Synthesis of substituted pyridines | [Uses]
3-Hydroxypiperidine is usually used for Synthesis of unsymmetrical ureas,Synthesis of piperidine nucleoside analogs,Fluorination reactions,Synthesis of substituted pyridines.
| [General Description]
3-Hydroxypiperidine can be obtained from the reduction of 3-hydroxypyridine. |
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