| Identification | Back Directory | [Name]
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE | [CAS]
67953-08-6 | [Synonyms]
H-GLU(PNA)-OH HCL
GPNA (hydrochloride)
gamma-L-Glutamyl-4-nitroanilideHCl
n-(4-nitrophenyl)-l-glutaminmonohydrochloride
L-GAMMA-GLUTAMYL 4-NITROANILIDE HYDROCHLORIDE
L-GAMMA-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE
GAMMA-L-GLUTAMYL-P-NITROANILIDE HYDROCHLORIDE
N-(4-nitrophenyl)-L-glutamine monohydrochloride
l-glutamic acid γ-(p-nitroanilide) hydrochloride
L-Glutamic acid g-(p-nitroanilide) hydrochloride
L-glutamic acid gamma-(P-nitroanilide)*hydrochlor
L-y-GLUTAMYL-p-NITROANILIDE HYDROCHLORIDE extrapure
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE) HYDROCHLORIDE
L-GLUTAMIC ACID GAMMA-(P-NITROANILIDE)*H YDROCHLORID
(3-carbaMoyl-1-carboxy-propyl)-(4-nitrophenyl)azaniuM chloride
(4-amino-1-carboxy-4-keto-butyl)-(4-nitrophenyl)ammonium chloride
(5-amino-1-hydroxy-1,5-dioxopentan-2-yl)-(4-nitrophenyl)azanium chloride
(5-azanyl-1-hydroxy-1,5-dioxo-pentan-2-yl)-(4-nitrophenyl)azanium chloride | [EINECS(EC#)]
267-944-5 | [Molecular Formula]
C11H14ClN3O5 | [MDL Number]
MFCD00039054 | [MOL File]
67953-08-6.mol | [Molecular Weight]
303.7 |
| Hazard Information | Back Directory | [Description]
L-γ-Glutamyl-p-nitroanilide (67953-08-6; GPNA) is a substrate for γ-glutamyl transpeptidase. GPNA is used for the determination of γ-glutamyl transpeptidase hydrolytic activity via spectrophotometric monitoring of p-nitroaniline released by the action of the enzyme on GPNA.1 GPNA has also been shown to be an inhibitor of glutamine uptake – solute-linked carrier family A1 member 5 (SLC1A5).2?Cellular uptake of L-glutamine (regulated by SLC1A5) is a rate-limiting step that activates mTOR and is, thus, an interesting cancer chemotherapy target.3 | [Uses]
L-Glutamic acid gamma-(p-nitroanilide) is used in methods of treating cancers having a deregulated NRF2/KEAP1 pathway. | [storage]
Store at 2-8°C | [References]
1) Meister?et al. (1981),?γ-Glutamyl transpeptidase; Methods Enzymol.,?77?237
2) Esslinger?et al. (2005),?N-gamma-aryl glutamine analogues as probes of the ASCT2 neutral amino acid transporter binding site; Bioorg. Med. Chem.,?13?1111
3) Nicklin?et al. (2012),?Bidirectional Transport of Amino Acid Regulates mTOR and Autophagy; Cell,?136?521 |
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