| Identification | More | [Name]
Diethylenetriaminepentaacetic acid | [CAS]
67-43-6 | [Synonyms]
(CARBOXYMETHYLIMINO)BIS(ETHYLENEDINITRILO)TETRAACETIC ACID
(CARBOXYMETHYLIMINO)BIS(ETHYLENENITRILO)TETRAACETIC ACID
COMPLEXONE V(R)
DETAPAC
DIETHYLENETRIAMINE-N,N,N',N'',N''-PENTAACETIC ACID
DIETHYLENETRIAMINEPENTAACETIC ACID
DIETHYLENETRIAMINEPENTACETIC ACID
(DIETHYLENETRINITRILO)PENTAACETIC ACID
DIPA
DTPA
DTRA
HAMPEX ACID
IDRANAL(R) V
LABOTEST-BB LT00452993
N,N-BIS(2-[BIS(CARBOXYMETHYL)AMINO]ETHYL)GLYCINE
PENTA(CARBOXYMETHYL)DIETHYLENETRIAMINE
PENTETIC ACID
TIMTEC-BB SBB008753
TITRIPLEX(R) V
TITRIPLEX(R) VS | [EINECS(EC#)]
200-652-8 | [Molecular Formula]
C14H23N3O10 | [MDL Number]
MFCD00004289 | [Molecular Weight]
393.35 | [MOL File]
67-43-6.mol |
| Chemical Properties | Back Directory | [Appearance]
solid | [Melting point ]
219-220 °C (lit.) | [Boiling point ]
517.84°C (rough estimate) | [density ]
1.56
| [refractive index ]
1.5700 (estimate) | [Fp ]
200 °C
| [storage temp. ]
room temp | [solubility ]
0.1 M NaOH: 0.1 M at 20 °C, clear, colorless
| [form ]
Crystalline Powder | [pka]
pK1:;pK2:2.55(+1);pK3:4.33(+2);pK4:8.60(-3);pK5,10.58 (25°C) | [color ]
White to almost white | [PH]
2-3 (H2O, 20℃)(saturated solution) | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
5 g/L (20 ºC) | [Merck ]
14,7125 | [BRN ]
1810219 | [InChIKey]
QPCDCPDFJACHGM-UHFFFAOYSA-N | [LogP]
-1.361 (est) | [CAS DataBase Reference]
67-43-6(CAS DataBase Reference) | [NIST Chemistry Reference]
N,N-Bis(2-(bis-(carboxymethyl)amino)ethyl)-glycine(67-43-6) | [EPA Substance Registry System]
67-43-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,N | [Risk Statements ]
R36:Irritating to the eyes.
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
2
| [RTECS ]
MB8205000
| [F ]
3 | [TSCA ]
Yes | [HazardClass ]
9 | [PackingGroup ]
III | [HS Code ]
29224995 | [Safety Profile]
Moderately toxic by
intraperitoneal route. When heated to
decomposition it emits toxic fumes of NOx. | [Toxicity]
LD50 orally in Rabbit: > 2000 mg/kg |
| Hazard Information | Back Directory | [Chemical Properties]
Diethylenetriaminepentaacetic acid is a solid. | [Chemical Properties]
Pentetic acid occurs as a white crystalline solid and is almost
odorless. | [Chemical Properties]
solid | [Uses]
chelating agent, diagnostic aid | [Uses]
Diethylenetriaminepentaacetic Acid is a component of manganese and zinc fertilizers. | [Definition]
ChEBI: Pentetic acid is a pentacarboxylic acid. It has a role as a copper chelator. It is a conjugate acid of a pentetate(1-). | [Production Methods]
Pentetic acid is a pentaacetic acid triamine formed during the
preparation of the amino carboxylic acid and its salt. | [General Description]
| [Pharmaceutical Applications]
Pentetic acid is mainly used as a chelating agent in the preparation
of imaging and contrast agents for radionuclide and magnetic
resonance imaging.It is also used as a carrier excipient for
neutron-capture isotopes in, for example, radiotherapy.Pentetic
acid–isotope complexes have also been considered as model active
substances in scintigraphic imaging studies.Pentetic acid has been
used to chelate metal ions to reduce formation of reactive oxygen
species during lyophilization. | [Safety]
Pentetic acid is used in intrathecal and intravenous injection
preparations. The pure form of pentetic acid is moderately toxic
by the intraperitoneal route.
LD50 (mouse, IP): 0.54 g/kg
LD50 (mouse, oral): 4.84 g/kg | [storage]
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation. | [Purification Methods]
Crystallise DTPA from water. Dry under vacuum or at 110o. [Bielski & Thomas J Am Chem Soc 109 7761 1987, NMR: Wenzel et al. Anal Chem 54 615 1982, Beilstein 4 IV 2454.] | [Incompatibilities]
The activity of pentetic acid as a chelating agent may cause
unwanted effects in formulations containing metal ions. The desired
chelate may be displaced by other ions from the formulation. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (intrathecal and
intravenous injections). Included in intravenous and intra-articular
injections licensed in the UK. |
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