| Identification | More | [Name]
5-CHLORO-2-NITROANISOLE | [CAS]
6627-53-8 | [Synonyms]
4-CHLORO-2-METHOXYNITROBENZENE
5-CHLORO-2-NITROANISOLE
4-chloro-2-methoxy-1-nitro-benzen
4-Chloro-2-methoxynitrobenzene 98%
4-chloro-2-methoxy-1-nitro-benzene
4-Chloro-3-methoxy-1-nitrobenzene
5-CHLORO-2-NITROANISOLE 97% | [EINECS(EC#)]
229-594-1 | [Molecular Formula]
C7H6ClNO3 | [MDL Number]
MFCD00007288 | [Molecular Weight]
187.58 | [MOL File]
6627-53-8.mol |
| Chemical Properties | Back Directory | [Appearance]
SLIGHTLY YELLOW TO GREEN CRYSTALLINE POWDER | [Melting point ]
70-72 °C(lit.)
| [Boiling point ]
289.1±20.0 °C(Predicted) | [density ]
1.4219 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Ethyl Acetate | [form ]
Solid | [color ]
Yellow | [CAS DataBase Reference]
6627-53-8(CAS DataBase Reference) | [EPA Substance Registry System]
6627-53-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
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| Hazard Information | Back Directory | [Chemical Properties]
SLIGHTLY YELLOW TO GREEN CRYSTALLINE POWDER | [Uses]
5-Chloro-2-nitroanisole is involved in the synthesis of orally bioavailable anaplastic lymphoma kinases (ALK) inhibitors as anticancer drugs. In addition it is used in the synthesis of kinesin spindle
protein (KSP) inhibitors which are responsible for the spindle pole separation which occurs during mitosis in cancer cells. |
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