| Identification | More | [Name]
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE | [CAS]
6533-68-2 | [Synonyms]
ATROSCINE HYDROBROMIDE TRIHYDRATE
HYOSCINE HYDROBROMIDE TRIHYDRATE
(-)-SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE
),hydrobromide,trihydrate
screen
tripton
SCOPOLAMINE HYDROBROMIDE USP
ScopolamineHydrobromideTrihydrate99%
Scopolaminhydrobromidetrihydrate
| [EINECS(EC#)]
613-776-6 | [Molecular Formula]
C17H28BrNO7 | [MDL Number]
MFCD00150066 | [Molecular Weight]
438.31 | [MOL File]
6533-68-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline solid | [Melting point ]
197-194 °C
| [refractive index ]
-25.5 ° (C=5, H2O) | [storage temp. ]
Poison room | [solubility ]
H2O: soluble50mg/mL | [form ]
Crystals or Crystalline Powder | [color ]
white to off-white | [Stability:]
Stable, but air and light sensitive. Incompatible with acids, bases, strong oxidizing agents. Slightly hygroscopic. | [optical activity]
[α]25/D 24 to 26°, c = 5 in H2O(lit.) | [Merck ]
8406 | [BRN ]
6100669 | [LogP]
0.760 (est) | [CAS DataBase Reference]
6533-68-2(CAS DataBase Reference) | [EPA Substance Registry System]
Scopolamine hydrobromide trihydrate (6533-68-2) |
| Safety Data | Back Directory | [Hazard Codes ]
T+ | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S25:Avoid contact with eyes .
S1:Keep locked up . | [RIDADR ]
UN1544 6.1/PG 3 | [WGK Germany ]
1 | [RTECS ]
YM4550000 | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29399990 |
| Hazard Information | Back Directory | [Description]
Scopolamine hydrobromide is a bronchodilator indicated for the maintenance treatment of chronic obstructive pulmonary disease (COPD), including chronic bronchitis and emphysema, the maintenance treatment of concomitant dyspnea and the prevention of acute exacerbations. | [Chemical Properties]
white crystalline solid | [Uses]
adrenergic agonist, nasal decongestant | [Definition]
ChEBI: Scopolamine hydrobromide trihydrate(6533-68-2) is a hydrate that is the trihydrate form of scopolamine hydrobromide. It has a role as a mydriatic agent, a muscarinic antagonist, an anaesthesia adjuvant, an antispasmodic drug and an antiemetic. It contains a scopolamine hydrobromide (anhydrous).
| [Brand name]
Isopto Hyoscine (Alcon); Transderm-Scop (Ciba-Geigy). | [General Description]
White orthorhombic sphenoidal crystals from water. pH of 0.05 molar solution: 5.85. | [Air & Water Reactions]
Is sensitive to air, light and moisture. Slightly efflorescent in dry air. | [Reactivity Profile]
SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is incompatible with acids, bases and oxidizing agents. . | [Fire Hazard]
Flash point data for SCOPOLAMINE HYDROBROMIDE TRIHYDRATE are not available. SCOPOLAMINE HYDROBROMIDE TRIHYDRATE is probably combustible. | [Mode of action]
Scopolamine Hydrobromide[6533-68-2] is a Belladonna Alkaloid with Anticholinergic Activity. It competitively inhibits muscarinic receptors of the parasympathetic nervous system for acetylcholine and act as a nonselective muscarinic antagonist, producing peripheral anti-muscarinic, central sedative and antiemetic effects. The parasympatholytic scopolamine, structurally very similar to atropine as well, is used in conditions requiring decreased parasympathetic activity. Therefore, scopolamine can inhibit the secretion of saliva and sweat, decrease gastrointestinal secretions and motility, and increase heart rate et al. | [References]
[1] KLINKENBERGINGE BloklandArjan. The validity of scopolamine as a pharmacological model for cognitive impairment: a review of animal behavioral studies.[J]. Neuroscience and Biobehavioral Reviews, 2010. DOI:10.1016/j.neubiorev.2010.04.001.
[2] CEYHAN T, KARTAL M, ALTUN M L, et al. LC determination of atropine sulfate and scopolamine hydrobromide in pharmaceuticals.[J]. Journal of pharmaceutical and biomedical analysis, 2001, 25 3-4: 399-406. DOI:10.1016/S0731-7085(00)00514-8.
[3] STEENKAMPP A. Fatal Datura poisoning: identification of atropine and scopolamine by high performance liquid chromatography/photodiode array/mass spectrometry.[J]. Forensic science international, 2004. DOI:10.1016/j.forsciint.2004.03.011.
[4] MUHTADI F J, HASSAN M M A. Analytical Profile Of Scopolamine Hydrobromide[C]//Vol. 19. 1990: 477-551. DOI:10.1016/S0099-5428(08)60376-7. |
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