| Identification | More | [Name]
4-Pyridyl acetone | [CAS]
6304-16-1 | [Synonyms]
1-(4-PYRIDINYL)-2-PROPANONE
1-(4-Pyridyl)acetone
1-(PYRIDIN-4-YL)PROPAN-2-ONE
(4-PYRIDYL)ACETONE
(PYRIDIN-4-YL)ACETONE
1-(4-Pyridyl)-2-propanone
4-Pyridinolacetone
(4-Pyridyl)acetone,98%
1-(4-Pyridinyl)-2-propanone CAS:
(4-PYRIDINEYL)-ACETONE
1-(4-Pyridyl)-2-acetone
4-ACETONYLPYRIDINE | [EINECS(EC#)]
228-605-7 | [Molecular Formula]
C8H9NO | [MDL Number]
MFCD00129043 | [Molecular Weight]
135.16 | [MOL File]
6304-16-1.mol |
| Questions And Answer | Back Directory | [Description]
1-(4-pyridyl)acetone is a yellow liquid, which is a key intermediate for synthesizing cardiac drug Milrinone. | [Preparation]
4-Pyridyl acetone can be prepared by reacting with 4-picoline and phenyllithium and ethyl acetate. |
| Chemical Properties | Back Directory | [Melting point ]
13°C | [Boiling point ]
143°C 20mm | [density ]
1.046±0.06 g/cm3(Predicted) | [refractive index ]
1.5225 | [Fp ]
143°C/20mm | [storage temp. ]
Inert atmosphere,Room Temperature | [solubility ]
Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
Oil | [pka]
4.90±0.10(Predicted) | [color ]
Light Brown to Brown | [Water Solubility ]
Slightly soluble in water. | [BRN ]
110960 | [InChIKey]
ILRVKOYYFFNXDB-UHFFFAOYSA-N | [CAS DataBase Reference]
6304-16-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [HS Code ]
29337900 |
| Hazard Information | Back Directory | [Physical properties]
4-pyridyl acetone is a Light yellow to yellow liquid. | [Uses]
(4-Pyridyl)acetone is a reactant in the synthesis of Milrinone (M344680), a selective phosphodiesterase inhibitor with vasodilating and positive inotropic activity. Cardiotonic. | [Synthesis Reference(s)]
Tetrahedron Letters, 25, p. 3297, 1984 DOI: 10.1016/S0040-4039(01)81368-X |
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