| Identification | More | [Name]
Monomethyl adipate | [CAS]
627-91-8 | [Synonyms]
ADIPIC ACID MONOMETHYL ESTER
hexanedioic acid monomethyl ester
METHYL ADIPATE
METHYL HYDROGEN ADIPATE
METHYL HYDROGEN HEXANE-1,6-DIOATE
MONO-METHYL ADIPATE
MONOMETHYL HEXANE-1,6-DIOATE
6-Methoxy-6-oxohexanoic acid
Methyl 5-carboxypentanoate
Methyl hemiadipate
fatty acid methyl ester
MonomethylAdipate98%
Methylhydrogeneadipate
Adipic acid methyl ester
Dihexanoic acid methyl ester
HEXANEDIOICACID,MONOMETHYLE
Methyladipinate
Adipic acid monomethyl ester, Monomethyl adipate
Adipic acid monomethyl ester, mono-Methyl adipate, Monomethyl adipate
5-Carbomethoxypentanoic acid | [EINECS(EC#)]
211-019-0 | [Molecular Formula]
C7H12O4 | [MDL Number]
MFCD00004418 | [Molecular Weight]
160.17 | [MOL File]
627-91-8.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
7-9 °C (lit.) | [Boiling point ]
162 °C/10 mmHg (lit.) | [density ]
1.081 g/mL at 25 °C(lit.)
| [vapor pressure ]
1.48Pa at 25℃ | [refractive index ]
n20/D 1.441(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
Chloroform (Sparingly), Methanol (Slightly) | [form ]
Liquid | [pka]
4.69±0.10(Predicted) | [color ]
Clear colorless | [Water Solubility ]
Not miscible or difficult to mix with water. | [BRN ]
1766411 | [LogP]
0.500 (est) | [CAS DataBase Reference]
627-91-8(CAS DataBase Reference) | [NIST Chemistry Reference]
Hexanedioic acid, monomethyl ester(627-91-8) | [EPA Substance Registry System]
627-91-8(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S24/25:Avoid contact with skin and eyes .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29171290 |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Methyl hydrogen adipate is a useful synthetic intermediate. It can be used to prepare 1,3,4-thiadiazole hydroxamic acid derivatives as novel histone deacetylase inhibitors which show potential antitumor activities. It can be also used to synthesize mannose-linked biphenylylacetic acid derivatives as novel inhibitors of selectin-mediated cell adhesion. | [Definition]
ChEBI: Monomethyl adipate is a dicarboxylic acid monoester that is the monomethyl ester of adipic acid. It has a role as a metabolite and a plasticiser. | [Synthesis]
According to the general procedure described above, a has been synthesized from adipic acid (730mg, 5 mmol) and methanol (10 ml). Yield: 80%.
The synthetic method of Monomethyl adipate mainly contains following three kinds:
The one, under alkaline condition or issue the first portion hydrolysis reaction in the catalysis of bioactive enzyme (pork liver lipase etc.) and obtain Monomethyl adipate (such as document Blaise; Koehler; Bulletin de la Societe Chimique deFrance; Vol. (4) 7; (1910); P.219).
The 2nd, by hexanodioic acid or adipic anhydride and ethanol, as catalyzer, the control reaction conditions carries out esterification and obtains Monomethyl adipate (such as document Chem.Zentralbl. with acid; Vol.97; (1926; P.126));
The 3rd, by the people such as Swann nineteen forty-three with hexanodioic acid, diethylene adipate and ethanol with the condition of acid as catalyst under control reaction conditions obtain monomethyl adipate(document such as Swann; Oehler; Buswell; Org.synth.Coll.Vol.11; (1943); P.227).
Synthetic method of monomethyl adipate
http://www.orgsyn.org/demo.aspx?prep=CV2P0264 |
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