| Identification | More | [Name]
4-Chloroanisole | [CAS]
623-12-1 | [Synonyms]
1-CHLORO-4-METHOXYBENZENE
4-CHLOROANISOLE
P-CHLOROANISOLE
1-chloro-4-methoxy-benzen
4-Chlorophenol methyl ether
Anisole, p-chloro-
Benzene,1-chloro-4-methoxy-
para-Chloroanisole
p-chloroanisol
p-Chloromethoxybenzene
p-Chlorophenyl methyl ether
4-Chloroanisol
4-CHLOROANISOLE PESTANAL
4-Chloroanisole,98%
3 4-Chloroanisole
4-Chlorophenyl methyl ether
2-methyl-4-chloro phenol，4-chloro anisole
4-Methoxyphenyl chloride
Methyl(4-chlorophenyl) ether | [EINECS(EC#)]
210-772-2 | [Molecular Formula]
C7H7ClO | [MDL Number]
MFCD00000616 | [Molecular Weight]
142.58 | [MOL File]
623-12-1.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Safety Statements ]
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
UN 2810 | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29093090 |
| Hazard Information | Back Directory | [Chemical Properties]
colourless liquid | [Uses]
4-Chloroanisole was found to react with Cu (II)-smectite forming a blue clay-organic complex. 4-Chloroanisole was chosen as the main test substrate for the optimisation studies as it is electronically deactivated and thus resistant to oxidative addition and consequently very reluctant to enter a catalytic manifold. | [Synthesis Reference(s)]
Chemistry Letters, 16, p. 1901, 1987
The Journal of Organic Chemistry, 35, p. 528, 1970 DOI: 10.1021/jo00827a060 | [General Description]
4-Chloroanisole is an electron-rich chloroarene. It undergoes Ullmann-type homocoupling catalyzed by in situ generated Pd colloids. Reaction of 4-chloroanisole with Cu(II)-smectite in n-hexane, carbon tetrachloride or dichloromethane has been studied. The nucleophilic photosubstitution reactions, photocyanation and photohydrolysis of 4-chloroanisole has been studied by time resolved spectroscopy. | [Purification Methods]
Wash the anisole with 10% (by volume) aqueous H2SO4 (three times), 10% aqueous KOH (three times), and then with water until neutral. Dry it (MgSO4), and fractionally distil it from CaH2 through a glass helices-packed column under reduced pressure. [Beilstein 16 IV 822.] |
|
|