| Identification | More | [Name]
6-CHLOROQUINOLINE | [CAS]
612-57-7 | [Synonyms]
6-CHLOROQUINOLINE
AKOS 100
6-chloro-quinolin
6-Chloroquinoline,99% | [EINECS(EC#)]
210-314-1 | [Molecular Formula]
C9H6ClN | [MDL Number]
MFCD00024024 | [Molecular Weight]
163.6 | [MOL File]
612-57-7.mol |
| Chemical Properties | Back Directory | [Appearance]
beige to brown crystals | [Melting point ]
41-43 °C (lit.) | [Boiling point ]
126-127 °C/10 mmHg (lit.) | [density ]
1.2108 (rough estimate) | [refractive index ]
1.6110 (estimate) | [Fp ]
>230 °F
| [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to lump | [pka]
4.18±0.10(Predicted) | [color ]
White to Light yellow to Light orange | [Water Solubility ]
Insoluble in water. | [BRN ]
112963 | [InChIKey]
GKJSZXGYFJBYRQ-UHFFFAOYSA-N | [CAS DataBase Reference]
612-57-7(CAS DataBase Reference) | [NIST Chemistry Reference]
Quinoline, 6-chloro-,(612-57-7) | [EPA Substance Registry System]
612-57-7(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [WGK Germany ]
3
| [TSCA ]
Yes | [HS Code ]
29334900 |
| Hazard Information | Back Directory | [Chemical Properties]
beige to brown crystals | [Uses]
Catalyst for high yield preparation of ethoxycarbonyl isothiocyanate. | [Uses]
6-chloroquinoline is a useful research chemical. | [Preparation]
All the reactions were carried out in a 50 mL stainless steel autoclave . A mixture of glycerol (1 g, 1 equiv.), aniline (0.58 g, 0.5 equiv.), water (2.5 mL) and W-KIT-6 (100 mg) was charged in to the autoclave simultaneously and finally heated to 200 °C with stirring for 3 h. On completion of the reaction (monitored by TLC), the autoclave was cooled to room temperature and the catalyst was removed by filtration. Ethyl acetate (10 mL) and water (5 mL) were added to the reaction mixture and stirred well for few minutes. The organic layer was dried over anhydrous Na2SO4 and the crude was purified by column chromatography using 60-120 mesh silica with ethylacetate/hexane as eluent to afford 6-chloroquinoline in good yield. | [General Description]
The standard molar enthalpy of formation of 6-chloroquinoline has been derived from the standard molar enthalpy of combustion and was evaluated in terms of molecular structure. Its arylation reaction with diamine derivatives of adamantanes in the presence of palladium catalyst has been reported to afford N,N′-diaryl derivatives. |
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