| Identification | More | [Name]
Linocaine hydrochloride | [CAS]
6108-05-0 | [Synonyms]
ACETAMIDE,2-(DIETHYLAMINO)-N-(2,6-DIMETHYLPHENYL)-MONOHYDROCHLORIDE, MONOHYDRATE
LIDOCAINE HCL HYDRATE
LIDOCAINE HYDROCHLORIDE
LIDOCAINE HYDROCHLORIDE, MONOHYDRATE
LINOCAINE HYDROCHLORIDE
2’,6’-acetoxylidide,2-(diethylamino)-,hydrochloride,hydrate
acetamide,2-(diethylamino)-n-(2,6-dimethylphenyl)-,monohydrochloride,monoh
diethylaminoacet-2,6-xylididehydrochloridemonohydrate
dolicaine
lidocainemonohydratehydrochloride
Lidocaine HCl USP
LidocaineHclLidocaineHclBp
2-diethylamino-n-(2,6-dimethylphenyl)acetamide hydrochloride monohydrate
LIDOCAINEHYDROCHLORIDE,MONOHYDRATE,USP
2-(Diethylamino)-N-(2,6-dimethylphenyl)acetamide hydrochloride
LIDOCAINE HYDROCHLORIDE DAB, PH.EUR.
LINOCAINE HCL
Lignocaine monohydrate hydrochloride, Xylocaine monohydrate hydrochloride, 2-Diethylamino-N-(2,6-dimethylphenyl)acetamide monohydrate hydrochloride
2-Dimethylamino-N-(2,6-dimethylphenyl)acetamide hydrochloride | [EINECS(EC#)]
200-803-8 | [Molecular Formula]
C14H25ClN2O2 | [MDL Number]
MFCD00150329 | [Molecular Weight]
288.81 | [MOL File]
6108-05-0.mol |
| Chemical Properties | Back Directory | [Appearance]
White or almost white, crystalline powder. | [Melting point ]
75-79℃ | [storage temp. ]
2-8°C | [solubility ]
H2O: soluble
| [form ]
solid
| [color ]
white
| [Water Solubility ]
Soluble in water (50 mg/ml), chloroform, ethanol, and benzene. Insoluble in diethyl ether. | [InChI]
InChI=1S/C14H22N2O.ClH.H2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4;;/h7-9H,5-6,10H2,1-4H3,(H,15,17);1H;1H2 | [Contact allergens]
Lidocaine is an anesthetic of the amide group, like articaine
or bupivacaine. Immediate-type IgE-dependent
reactions are rare, and delayed-type contact dermatitis
is exceptional. Cross-reactivity between the different
amide anesthetics is not systematic. | [InChIKey]
YECIFGHRMFEPJK-UHFFFAOYSA-N | [SMILES]
C1(C(C)=CC=CC=1C)NC(=O)CN(CC)CC.O.Cl | [LogP]
2.359 (est) | [CAS DataBase Reference]
6108-05-0(CAS DataBase Reference) |
| Hazard Information | Back Directory | [Uses]
A fast voltage-gated sodium channel blocker | [Uses]
Na+ channel blocker. | [Uses]
used in Local anesthesia and heart rhythm disorders. | [Definition]
ChEBI: The monohydrate form of lidocaine hydrochloride. | [Chemical Properties]
Linocaine hydrochloride is white or almost white, crystalline powder.
| [Application]
Anesthetic (local); antiarrhythmic (class IB). Long-acting, membrane stabilizing agent against ventricular arrhythmia. Originally developed as a local anesthetic. | [Brand name]
Alpha caine Hydrochloride (Carlisle); Anestacon (Polymedica);
Laryng-O-Jet (International Medication); Lidocaton (Phar maton); Lidopen (Meridian); Xylocaine (Abraxis); Xylo caine (AstraZeneca); Xylocaine (Dentsply). | [General Description]
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Mode of action]
Lidocaine Hydrochloride is the hydrochloride salt form of lidocaine, an aminoethylamide and a prototypical member of the amide class anesthetics. Lidocaine interacts with voltage-gated Na+ channels in the nerve cell membrane and blocks the transient increase in permeability of excitable membranes to Na+. This prevents the generation and conduction of nerve impulses and produces a reversible loss of sensation. Lidocaine hydrochloride also exhibits class IB antiarrhythmic effects. The agent decreases the flow of sodium ions into myocardial tissue, especially on the Purkinje network, during phase 0 of the action potential, thereby decreasing depolarization, automaticity and excitability. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
AN7700000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [HS Code ]
2924296000 |
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