| Identification | More | [Name]
TETRAMETHYLTIN | [CAS]
594-27-4 | [Synonyms]
TETRAMETHYLSTANNANE
TETRAMETHYLTIN
TETRAMETHYLTIN(IV)
TIN TETRAMETHYL
(CH3)4Sn
Tetramethylcin
tetramethyl-stannan
tetramethyl-ti
TETRAMETHYLTIN, 99+%
Tetramethyltin,98%
Stannane, tetramethyl-
tatramethyl stannane | [EINECS(EC#)]
209-833-6 | [Molecular Formula]
C4H12Sn | [MDL Number]
MFCD00008278 | [Molecular Weight]
178.85 | [MOL File]
594-27-4.mol |
| Chemical Properties | Back Directory | [Appearance]
clear colorless liquid | [Melting point ]
−54 °C(lit.) | [Boiling point ]
74-75 °C(lit.) | [density ]
1.291 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.441(lit.)
| [Fp ]
9 °F
| [storage temp. ]
2-8°C
| [form ]
liquid | [color ]
colorless | [Specific Gravity]
1.291 | [Water Solubility ]
Insoluble in water. Soluble in organic solvents | [Hydrolytic Sensitivity]
1: no significant reaction with aqueous systems | [BRN ]
3647887 | [CAS DataBase Reference]
594-27-4(CAS DataBase Reference) | [EPA Substance Registry System]
Stannane, tetramethyl- (594-27-4) |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N | [Risk Statements ]
R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S27:Take off immediately all contaminated clothing .
S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3384 6.1/PG 1
| [WGK Germany ]
2
| [RTECS ]
WH8630000
| [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
II | [HS Code ]
29310099 | [Safety Profile]
Moderately toxic by inhalation. A very dangerous fire and explosion hazard when exposed to heat, flame, or oxidizers. Powerful explosive reaction with dinitrogen tetroxide. To fight fire, use water, foam, CO2, dry chemical. When heated it emits acrid smoke and irritating fumes. See also TIN COMPOUNDS and ORGANOMETALS. |
| Hazard Information | Back Directory | [Chemical Properties]
clear colorless liquid | [Uses]
Tetramethylstannane is used in preparation of Biphenyl Pyrazines as PD-1/PD-L1 inhibitors for treating cancer. | [Uses]
Tetramethyltin is used in many organic syntheticreactions. | [Definition]
ChEBI: An organotin compound carrying four methyl groups. | [Health Hazard]
Tetramethyltin is moderately toxic by allroutes of exposure. The symptoms includeheadache, muscle weakness, and paralysis.Exposure limits:
TLV-TWA: 0.1 mg (Sn)/m3 (skin) (ACGIH)
PEL-TWA: 0.1 mg (Sn)/m3 (skin) (OSHA). | [Fire Hazard]
The ease of oxidation, however, is low in
comparison with most other metal alkyls. It
is relatively stable to air and does not ignite spontaneously as other alkyls do. Also, it
is stable in water. The compound, however,
is highly flammable, the flash point being
( －13°C) 9°F (Aldrich 1996). It explodes
violently in contact with dinitrogen tetraoxide
even, at －80°C (－112°F) (Bailar 1973).
Reaction with strong oxidizers is expected to
be vigorous to violent. | [Purification Methods]
It is purified by fractionation using a Todd column (p 11) of 35-40 plates at atmospheric pressure. The purity of the fractions can be followed by IR [Edgell & Ward J Am Chem Soc 77 6486 1955]. It readily dissolves stopcock silicone greases which give bands in the 8-10a region. [Edgell & Ward J Am Chem Soc 76 1169 1954, Beilstein 4 IV 4307.] |
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