| Identification | More | [Name]
3,5-Lutidine | [CAS]
591-22-0 | [Synonyms]
3,5-DIMETHYLPYRIDINE
35L
3,5-LUTIDINE
3,5-dimethyl-pyridin
pyridine,3,5-dimethyl-
Lutidine,98%
3 5-LUTIDINE STANDARD FOR GC
3,5-LUTIDINE, 98+%
3,5-DIMETHYLPYRIDINE 98+%
3,5-Dimetylpyridine
3,5-Lutidine,99%
3,5-LUTIDINE 3,5-DIMETHYLPYRIDINE | [EINECS(EC#)]
209-708-6 | [Molecular Formula]
C7H9N | [MDL Number]
MFCD00006404 | [Molecular Weight]
107.15 | [MOL File]
591-22-0.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR YELLOW LIQUID | [Melting point ]
-9 °C (lit.) | [Boiling point ]
169-170 °C (lit.) | [density ]
0.939 g/mL at 25 °C(lit.)
| [vapor pressure ]
1.5 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.504(lit.)
| [Fp ]
128 °F
| [storage temp. ]
2-8°C
| [solubility ]
Sol | [form ]
Liquid | [pka]
6.15(at 25℃) | [color ]
Clear yellow | [Water Solubility ]
33 g/L (20 ºC) | [Sensitive ]
Hygroscopic | [Detection Methods]
GC | [BRN ]
105682 | [InChIKey]
HWWYDZCSSYKIAD-UHFFFAOYSA-N | [LogP]
1.780 | [CAS DataBase Reference]
591-22-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Pyridine, 3,5-dimethyl-(591-22-0) | [EPA Substance Registry System]
591-22-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,F,Xi | [Risk Statements ]
R10:Flammable.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R36/37/38:Irritating to eyes, respiratory system and skin .
R41:Risk of serious damage to eyes. | [Safety Statements ]
S16:Keep away from sources of ignition-No smoking .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S36/37:Wear suitable protective clothing and gloves . | [RIDADR ]
UN 1993 3/PG 3
| [WGK Germany ]
3
| [F ]
8 | [Hazard Note ]
Irritant/Flammable | [TSCA ]
Yes | [HazardClass ]
3 | [PackingGroup ]
III | [HS Code ]
29333999 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
Methyl vinyl sulfone | [Preparation Products]
5-Methylpyridin-3-amine-->3,5-DIMETHYLPYRIDIN-4-AMINE-->3,5-bis(chloromethyl)pyridine-->ETHYL METHYLPHOSPHONIC ACID-->3-CYANO-5-METHYLPYRIDINE-->METHYL 5-METHYLNICOTINATE-->2,3,5-Collidine-->1,3,5-Trimethyl-1,2-dihydropyridin-2-one-->1H-Pyrrolo[2,3-b]pyridine, 4-chloro-2-(1,1-diMethylethyl)-5-Methyl--->3,5-Dimethylpiperidine-->3,5-dimethylpyridine-4-carboxylic acid |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR YELLOW LIQUID | [Uses]
3,5-Lutidine is a reactant used in the synthesis of phthalazine and pyrazine compounds, as well as other pharmaceuticals. | [Synthesis Reference(s)]
Synthesis, p. 573, 1994 DOI: 10.1055/s-1994-25526 | [Flammability and Explosibility]
Flammable | [Purification Methods]
Dry 3,5-lutidine with sodium and fractionally distil it through a Todd column (p 11) packed with glass helices. Dissolve (100mL) in dilute HCl (1:4) and steam distil this until 1L of distillate is collected. Excess conc NaOH is added to the residue which is again steam distilled. The base is extracted from the distillate, using diethyl ether. The extract is dried over K2CO3, and distilled. It is then fractionally crystallised by partial freezing. The hydrochloride has m 229o(sublimes at 190-231o), and the picrate has m 242-243o(dec, from H2O), 249-250o(dec, from AcOH). [Beilstein 20 II 161, 20 III/IV 2788, 20/6 V 60.] |
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