| Identification | More | [Name]
Oxindole | [CAS]
59-48-3 | [Synonyms]
1,3-DIHYDRO-2H-INDOL-2-ONE
1,3-DIHYDRO-INDOLE-2-ONE
2-(AMINOPHENYL)ACETIC ACID LACTAM
2-HYDROXYINDOLE
2-INDOLINONE
2-KETOINDOLINE
2-OXINDOLE
AKOS B028811
INDOLIN-2-ONE
INDOLINONE, 2-
O-(AMINOPHENYL)ACETIC ACID LACTAM
OXINDOL
OXINDOLE
TIMTEC-BB SBB004215
1,3-dihydro-2h-indol-2-on
1,3-Dihydro-indol-2-one
1,3-Dihydroindol-2-one
2,3-dihydroindol-2-one
2,3-Dihydroindole-2-one
2H-Indol-2-one,1,3-dihydro- | [EINECS(EC#)]
200-429-5 | [Molecular Formula]
C8H7NO | [MDL Number]
MFCD00005711 | [Molecular Weight]
133.15 | [MOL File]
59-48-3.mol |
| Chemical Properties | Back Directory | [Appearance]
beige to yellowish-orange or pinkish-brown powder | [Melting point ]
123-128 °C(lit.) | [Boiling point ]
227 °C73 mm Hg(lit.) | [density ]
1.1475 (rough estimate) | [refractive index ]
1.5282 (estimate) | [Fp ]
194-196°C/17mm | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
9.1g/l | [form ]
Solid | [pka]
14.77±0.20(Predicted) | [color ]
Light Brown | [Water Solubility ]
insoluble | [Usage]
Indole analogue; shows pharmacological activity | [Detection Methods]
HPLC,NMR | [BRN ]
114692 | [CAS DataBase Reference]
59-48-3(CAS DataBase Reference) | [NIST Chemistry Reference]
2H-Indol-2-one, 1,3-dihydro-(59-48-3) | [EPA Substance Registry System]
59-48-3(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S22:Do not breathe dust .
S24/25:Avoid contact with skin and eyes . | [RIDADR ]
2811 | [WGK Germany ]
3
| [RTECS ]
NM2080500
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29337900 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
4-chlorobenzo[d]oxazol-2(3H)-one-->2',6'-Dichloroformanilide-->1-(2,6-Dichlorophenyl)indolin-2-one-->Benzene, 1,3-dichloro-2-isocyano- (9CI)-->Diclofenac sodium-->2,6-Dichlorophenyl isocyanate-->9(10H)-Acridinone, 4-chloro--->2,6-Dichloronitrobenzene-->2,6-DICHLORODIPHENYLAMINE | [Preparation Products]
5-Bromo-2-oxindole-->5-Acetyloxindole-->10,15-Dihydro-5H-diindolo[3,2-a:3',2'-c]carbazole-->3-[(2,4-Dimethylpyrrol-5-yl)methylidenyl]-2-indolinon-->5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL) INDOLIN-2-ONE-->1-METHYL-2-INDOLINONE |
| Hazard Information | Back Directory | [Chemical Properties]
beige to yellowish-orange or pinkish-brown powder | [Uses]
Indole analogue; shows pharmacological activity | [Uses]
Oxindole is considered as indole analogue, which shows pharmacological activity. | [Definition]
ChEBI: An indolinone carrying an oxo group at position 2. | [Hazard]
Causes flaccid paralysis without anesthesia (usually neuromuscular blockage), changes in motor activity, and ataxia in oral and intraperitoneal lethal-dose studies of mice; May cause irritation; Harmful by ingestion. | [Solubility in organics]
Oxindole is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of oxindole in ethanol and DMF is approximately 10 mg/ml and approximately 3 mg/ml in DMSO. Oxindole is sparingly soluble in aqueous buffers. |
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