| Identification | More | [Name]
Pyridoxine hydrochloride | [CAS]
58-56-0 | [Synonyms]
PYRIDOXINE-D4 HCL
3-hydroxy-4,5-dimethylol-alpha-picolinehydrochloride
4,5-bis(hydroxymethyl)-2-methylpyridin-3-olhydrochloride
4,5-bis(hydroxymethyl)-3-hydroxy-2-methylpyridinehydrochloride
4-pyridinedimethanol,5-hydroxy-6-methyl-hydrochloride
5-hydroxy-6-methyl-3,4-pyridinedicarbinolhydrochloride
aderominehydrochloride
aderoxin
aderoxine
becilan
benadon
bonasanit
campoviton6
hexabetalin
hexa-betalin(r)
hexabionehydrochloride
hexavibex
hexermin
hexobion
paxadon | [EINECS(EC#)]
200-386-2 | [Molecular Formula]
C8H12ClNO3 | [MDL Number]
MFCD08064207 | [Molecular Weight]
205.64 | [MOL File]
58-56-0.mol |
| Chemical Properties | Back Directory | [Definition]
An aldehyde
derivative of pyridoxine, with vitamin B6activity, | [Appearance]
Crystalline | [Melting point ]
214-215 °C(lit.)
| [density ]
1.2784 (rough estimate) | [vapor density ]
7.1 (vs air)
| [refractive index ]
1.5800 (estimate) | [Fp ]
9℃ | [storage temp. ]
2-8°C
| [solubility ]
H2O: 0.1 g/mL at 20 °C, clear, colorless
| [form ]
Crystalline Powder | [color ]
White to almost white | [PH Range]
3.2 | [Stability:]
Stable. Protect from air and light. | [Water Solubility ]
0.1 g/mL (20 ºC) | [Sensitive ]
Light Sensitive | [Usage]
One of the vitamins of the B6 complex; present in many foodstuffs (yeast, liver and cereals). It has a role in transporting protein Bsu1, contributes to thiamine uptake; characterization of thiamine (vitamin B1) transporter Thi9 from Schizosaccharom | [Merck ]
14,7982 | [BRN ]
3632435 | [BCS Class]
1 | [LogP]
-1.098 (est) | [Uses]
Pyridoxine Hydrochloride(58-56-0) is an acid form of vitamin b6, a water-
soluble vitamin. it is soluble in water, and slightly soluble in alco-
hol. it is slowly affected by sunlight and is reasonably stable in air.
it has a ph of 2.3–3.5. it is also termed vitamin b6 hydrochloride.
see pyridoxine.
| [CAS DataBase Reference]
58-56-0(CAS DataBase Reference) | [EPA Substance Registry System]
58-56-0(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN1230 - class 3 - PG 2 - Methanol, solution | [WGK Germany ]
2
| [RTECS ]
UV1350000
| [F ]
8-10 | [TSCA ]
Yes | [HS Code ]
29362500 | [Safety Profile]
Poison by intravenous route. Moderately toxic by ingestion, intramuscular, and subcutaneous routes. Human reproductive effects by ingestion and intramuscular routes: postpartum changes. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. | [Hazardous Substances Data]
58-56-0(Hazardous Substances Data) |
| Questions And Answer | Back Directory | [Nutrition supplements]
Pyridoxine hydrochloride(58-56-0) is the hydrochloride salt of Vitamin B6. Vitamin B6 (B6) is a water-soluble vitamin, which can be found in various foods such as fish, poultry, whole grains, legumes, banana, nuts, and sesame.Vitamin B6 has an important role in the metabolism of amino acids as a coenzyme, pyridoxal 5'-phosphate.
B6 may exert an anticolon tumor effect by the protection of the colon epithelium from damage in rats treated with 1,2-dimethylhidrazine (DMH) and to decreased lithocholic acid, a colon carcinogen. Vitamin B6 may prevent such diseases by lowering inflammation.
|
| Hazard Information | Back Directory | [Chemical Properties]
White or almost white, crystalline powder. | [Application]
Pyridoxine hydrochloride(58-56-0) has been used:
As a vitamin component in a chemically defined diet with balanced metal content for metal depletion studies;
As a component of chemically defined medium (CDM) to culture Staphylococcus aureus WSPPA;
As analytical reference standards for the determination of analytes in pharmaceutical preparations by chromatography and spectrophotometric techniques;
As a vitamin to study the impact of protein expression and post-translational modifications specifically charge heterogeneity;
As a medicine, it is used to prevent or treat certain neurological disorders (peripheral neuropathy) caused by certain drugs (e.g. isoniazid). It is also used in the treatment of certain hereditary disorders (e.g. flavoururic aciduria, hyperoxaluria, homocystinuria).
| [Brand name]
Hexa-Betalin (Lilly). | [General Description]
Vitamin B6 has six forms namely, pyridoxal, pyridoxine, pyridoxamine, pyridoxamine 5′-phosphate, pyridoxine 5′-phosphate and pyridoxal 5′-phosphate. Pyridoxine is a is a water-soluble vitamin and a pyrimidine derivative of vitamin B6. It is considered heat and acid stable. | [Biochem/physiol Actions]
Vitamin B6 is an essential coenzyme for amino acid, carbohydrate and lipid metabolism. Pyridoxine serves as a primary source in multivitamins. Pyridoxine deficiency is associated with peripheral neuropathy. | [Clinical Use]
Vitamin B6 | [Side effects]
Common side effects of Pyridoxine hydrochloride include: headache, nausea, drowsiness, mild numbness or tingling. Serious allergic reactions are rare and include: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, difficulty breathing, decreased sensation of touch, temperature, and vibration; loss of balance or coordination. If serious side effects occur please seek medical attention. | [Drug interactions]
Potentially hazardous interactions with other drugs
None known | [Metabolism]
Pyridoxine is metabolised to its active form pyridoxamine
phosphate. It is stored mainly in the liver where there
is oxidation to 4-pyridoxic acid and other inactive
metabolites which are excreted in the urine. | [Purification Methods]
Purify the vitamin by recrystallisation from EtOH/Me2CO, n-BuOH or MeOH/Et2O. Its solubility in H2O is 22%, and in EtOH it is 1.1%. It is insoluble in Et2O and CHCl3. Acidic aqueous solutions are stable at 120o/30minute. The free base has m 159-160o after recrystallisation from Me2CO and sublimation at 140-145o/0.0001mm. It has UV max at 290nm ( 84,000), 253 and 325nm ( 3,700 and 7,100) in 0.1N aqueous HCl. [Khua & Wendt Chem Ber 71 780 1938, 72 311 1939, Harris & Folkers J Am Chem Soc 61 1242 1939, Harris et al. J Am Chem Soc 62 3198 1940, Beilstein 21/5 V 492.] |
|
|