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ChemicalBook--->CAS DataBase List--->57837-19-1

57837-19-1

57837-19-1 Structure

57837-19-1 Structure
IdentificationMore
[Name]

Metalaxyl
[CAS]

57837-19-1
[Synonyms]

ALLEGIANCE
AMILAXYL
APRON
APRON(R)
FORAXYL
INFRA
LABOTEST-BB LT00134856
'LGC' (1638)
METALAXIL
METALAXYL
METAX
METHYL N-(2,6-DIMETHYL-PHENYL)-N-(2'-METHOXYACETYL)-DL-ALANINATE
METHYL N-(2-METHOXYACETYL)-N-(2,6-XYLYL)-DL-ALANINATE
MILOR
N-(2,6-DIMETHYLPHENYL)-N-(METHOXY-ACETYL)-ALANINE METHYL ESTER
(r)-2-{(2,6-dimethylphenylmethoxy)acetylamino}-propionic acid methyl ester
RIDOMIL
RIDOMIL(R)
Ridonil
SALOR-INT L497002-1EA
[EINECS(EC#)]

260-979-7
[Molecular Formula]

C15H21NO4
[MDL Number]

MFCD00055447
[Molecular Weight]

279.33
[MOL File]

57837-19-1.mol
Chemical PropertiesBack Directory
[Appearance]

Combustible, white crystalline solid or powder. Odorless.
[Melting point ]

72-73°C
[Boiling point ]

422.1°C (rough estimate)
[density ]

1.1083 (rough estimate)
[vapor pressure ]

7.5 x 10-4 Pa (25 °C)
[refractive index ]

1.5130 (estimate)
[Fp ]

100 °C
[storage temp. ]

APPROX 4°C
[solubility ]

Chloroform (Slightly), Methanol (Slightly)
[form ]

neat
[pka]

1.41±0.50(Predicted)
[color ]

Off-White to Pale Beige
[Water Solubility ]

0.84 g/100 mL
[BRN ]

2947777
[CAS DataBase Reference]

57837-19-1(CAS DataBase Reference)
[NIST Chemistry Reference]

Dl-alanine, n-(2,6-dimethylphenyl)-n-(methoxyacetyl)-, methyl ester(57837-19-1)
[EPA Substance Registry System]

57837-19-1(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

Xn,F
[Risk Statements ]

R22:Harmful if swallowed.
R43:May cause sensitization by skin contact.
R52/53:Harmful to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36:Irritating to the eyes.
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable.
[Safety Statements ]

S13:Keep away from food, drink and animal feeding stuffs .
S24:Avoid contact with skin .
S37:Wear suitable gloves .
S46:If swallowed, seek medical advice immediately and show this container or label .
S61:Avoid release to the environment. Refer to special instructions safety data sheet .
S36:Wear suitable protective clothing .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S16:Keep away from sources of ignition-No smoking .
[RIDADR ]

UN 1648 3/PG 2
[WGK Germany ]

2
[RTECS ]

AY6910000
[HS Code ]

29242990
[Safety Profile]

Moderately toxic by ingestion. When heated to decomposition it emits toxic fumes of NOx.
[Hazardous Substances Data]

57837-19-1(Hazardous Substances Data)
[Toxicity]

LD50 in rats (mg/kg): 669 orally (Urech)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Sodium carbonate-->Formaldehyde-->Phosphorus trichloride-->Calcium chloride-->Chloroacetic acid-->PHOSGENE-->Propionic acid-->m-Xylene-->L-Alanine-->2,6-Dimethylaniline-->Dehydrolyzing agent-->Methyl propionate-->Methoxyacetyl chloride-->2,6-Dimethyl-1-nitrobenzene-->4-Nitro-1,3-dimethylbenzene-->2-Chloropropionyl chloride-->Methoxyacetic acid-->Methyl 2-bromopropionate
[Preparation Products]

Metalaxy1+Propamocarb,W.P.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Apron(57837-19-1).msds
Hazard InformationBack Directory
[Hazard]

Moderately toxic by ingestion.
[Potential Exposure]

Metalaxyl is phenylamide systemic fungicide used on a variety of food and nonfood crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soil-borne pathogens. Banned for use in EU.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions) if breathing has stopped, and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Do not induce vomiting when formulations containing petroleum solvents are ingested. Otherwise, give large quantities of water and induce vomiting. Do not make an unconscious person vomit.
[Shipping]

UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous hazardous material, Technical Name Required.
[Incompatibilities]

Incompatible with alkaline materials, strong acids, oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Compounds of the carboxyl group react with all bases, both inorganic and organic (i.e., amines) releasing substantial heat, water and a salt that may be harmful. Incompatible with arsenic compounds (releases hydrogen cyanide gas), diazo compounds, dithiocarbamates, isocyanates, mercaptans, nitrides, and sulfides (releasing heat, toxic, and possibly flammable gases), thiosulfates and dithionites (releasing hydrogen sulfate and oxides of sulfur).
[Chemical Properties]

Combustible, white crystalline solid or powder. Odorless.
[Chemical Properties]

Pale Beige Solid
[Waste Disposal]

Small amounts may be destroyed by alkaline hydrolysis. Admixture with alkali can be followed by soil burial. Larger quantities can be disposed of by incineration in admixture with acetone or xylene and using effluent gas scrubbing. Do not reuse empty container; proper disposal required.
[Uses]

Agricultural fungicide. Phenylamide fungicide or use in food crops, shrubs and turf.
[Uses]

Metalaxyl is used for the control of air-borne pathogens by foliar application and of soil-borne pathogens by soil application on a wide range of crops. It is particularly useful against Oomycetes including soil-borne Phytophthora diseases.
[Uses]

Systemic fungicide used to control a variety of diseases on a wide range of temperate, subtropical and tropical crops.
[Definition]

ChEBI: Methyl N-(2,6-dimethylphenyl)-N-(methoxyacetyl)alaninate is an alanine derivative that is methyl alaninate in which one of the hydrogens attached to the nitrogen is substituted by a methoxyacetyl group, while the other is substituted by a 2,6-dimethylphenyl group. It is an alanine derivative, an aromatic amide, a carboxamide, an ether and a methyl ester.
[Agricultural Uses]

Fungicide: Metalaxyl is used as a systemic fungicide on a variety of food and non-food crops including tobacco, turf and conifers, and ornamentals. Used in combination with fungicides of different mode of action as a foliar spray on tropical and subtropical crops; as a seed treatment to control downy mildew; and as a soil fumigant to control soilborne pathogens.
[Trade name]

AGROX® PREMIERE; ALLEGIENCE®; APRON®; CG 117®; CGA-48988®; CHLORAXYL®; COTGUARD®; EPERON®; DELTA-COAT; FOLIO® GOLD; GAUCHO®; KODIAK®; METALAXIL®; METAXANIN®; PACE®; PREVAIL®; RAXIL® (tebu- conazole + metalaxyl); RIDOMIL® GOLD/BRAVO®; RIDOMIL®; RIDOMIL 2E®; SUBDUE®
[Pharmacology]

In mycelium of Phytophthora megasperma,metalaxyl affected primarily rRNA synthesis (polymerase I), whereas mRNA was much less sensitive; therefore, inhibition of rRNA synthesis is considered as the primary site of action of PAFs (23).
The PAFs exhibit strong preventive and curative activity. They affect especially hyphal growth (inside and outside the plant tissue) as well as haustorium and spore formation (15). Although not fully utilized for resistance management reasons, PAFs also exhibit strong eradicative and antisporulant activity in the disease cycle of target pathogens. On the other hand, PAFs do not inhibit the early stages in the disease cycle like zoospore release, spore germination, and penetration of the host tissue (15). Because spores contain many ribosomes to support early growth stages, RNA synthesis is fully operating only after spore germination; later development stages are therefore most sensitive to PAFs (23). As a consequence of RNA inhibition, the precursors of RNA synthesis (i.e., nucleoside triphosphates) are accumulated; they activate β-1,3-glucansynthetases, which are involved in cell wall formation (23). Metalaxyl-treated hyphae often produce thicker cell walls than do untreated ones.
[Environmental Fate]

Soil. Little information is available on the degradation of metalaxyl in soil; however, Sharom and Edgington (1986) reported metalaxyl acid as a possible metabolite. Repeated applications of metalaxyl decreases its persistence. Following an initial application, the average half-life was 28 days. After repeated applications, the half-life decreased to 14 days (Bailey and Coffey, 1985).
Carsel et al. (1986) studied the persistence of metalaxyl in various soil types. The application rate was 2.2 kg/ha. In a fine sand, metalaxyl concentrations at soil depths of 15, 20, 45 and 60 cm were 100, 150, 100 and 75 ppb, respectively, 55 days after
Plant. In plants, metalaxyl undergoes ring oxidation, methyl ester hydrolysis, ether cleavage, ring methyl hydroxylation and N-dealkylation (Owen and Donzel, 1986). Metalaxyl acid was identified as a hydrolysis product in both sunflower leaves an
In pigeon peas, metalaxyl may persist up to 12 days (Indira et al., 1981; Chaube et al., 1984).
[Metabolic pathway]

O-Demethylation is one of the major routes of metalaxyl degradation in the plant cell suspension culture. Although hydroxylation of methyl groups in the phenyl ring predominates in both lettuce and grapes, species differences are evident in grapes, whereas N-dealkylation and aryl hydroxylation are less important in lettuce. Two isomeric metabolites of methyl hydroxylation and the hydroxylated metabolite of the phenyl ring are identified as fungus metabolites. By UV irradiation of metalaxyl in aqueous solution, two rearrangement products of the N-acyl group to the 4-position on the phenyl ring are identified.
[Metabolism]

The degradation pathways of pesticides are published in the "FAO Plant Production and Protection Papers." Because the degradation pathways are similar for all PAF). In plants, metalaxyl is metabolized by four types of phase I reaction to form eight metabolites; at phase II, most of the metabolites are sugar-conjugated. The types of reaction in phase I are hydroxylation at the phenyl ring, oxidation of one of the tolylic methyl groups (Formula d), hydrolysis of the methyl ester (Formula e), and ether cleavage (Formula b). In phases II and III, there is also a dealkylation of the nitrogen (Formula l), in addition to the combination of the above-mentioned reaction types forming the compounds of Formulas f, h, and m. In mammals, following oral administration, metalaxyl is rapidly absorbed and rapidly and almost completely eliminated with urine and feces. Metabolism proceeds via the same degradation pathways as in plants, leading to products containing an oxidized tolylic methyl group with or without the hydrolyzed ester function (Formulas d, h, and i, respectively) containing a dealkylated nitrogen and a hydroxy group formed by ether cleavage (Formula l via b or e/f), containing an oxalyl function formed by ether cleavage followed by oxidation of the generated alcohol (Formula c), and containing the hydroxylated phenyl ring (Formula a). Residues in tissues were generally low, and there was no evidence for accumulation or retention of metalaxyl or its metabolites. In soil, similar degradation products are found as in plants and animals with the exception of three additional products of Formulas k, n, and g.
[Degradation]

Metalaxyl is very stable in neutral and acidic media at room temperature and it is reasonably stable to aqueous photolysis. Its calculated half-lives in buffers at 25 °C below pH 7 are <3 years and at pH 9, 12 weeks. Only at pH 11 was measurable hydrolysis seen (half-life 1.6 days) (Melkebeke et al., 1986). Thus environmental degradation can be expected to be slow.
[14C-phenyl]Metalaxy1ir radiated in aqueous solution with UV light at 30 °C was degraded with a half-life of 2-3 days at four pH values between 2.8 and 8.8. Acetone (1%) accelerated the rate of decomposition. Two rearrangement products (2 and 3) were isolated at pH 6.8; these accounted for 3 and 6% of the radioactivity, respectively. Irradiation of 2 showed that it was a precursor of compound 3 (Yao et al., 1989). Though these products appear to be unusual, there is a precedent for such reactions and the structures were determined by 1H and 13C NMR spectroscopy.
Decomposition under simulated sunlight was slower with a half-life of 297 days (Pirisi et al., 1996). Amide bond cleavage and N-dealkylation to compounds 4 and 5 was reported. The dimethylaniline (6) was a putative product but a separate experiment showed that it was degraded at a higher rate than the parent and so was not observed from metalaxyl. The products are shown in Scheme 1.
[Toxicity evaluation]

If used according to label recommendations, PAFs are considered to be safe to humans, animals, and the environment. The active ingredients represent only low-to-moderate acute oral and dermal hazard to rats, mice, and rabbits. The compounds do not exhibit mutagenic, oncogenic, and teratogenic hazards. No or only weak (furalaxyl, ofurace) skin irritant potential exists in rabbits and no skin sensitization is present in guinea pigs, whereas some compounds are weak to serious eye irritants in rabbits (except benalaxyl and oxadixyl). In long-term toxicity studies, the "no-observableeffect level" (NOEL) in rats is 2.5 mg/kg body weight/day for metalaxyl, metalaxyl-M, and ofurace; 5 mg/kg for benalaxyl; and 11 mg/kg for oxadixyl, whereas in dogs, the NOEL is 8.0 mg/kg body weight/day for metalaxyl and metalaxyl-M, 7 mg/kg for benalaxyl, and 12 mg/kg for oxadixyl. Using a safety factor of 100, the "acceptable daily intake" (ADI) for PAFs ranges from 0.025 to 0.11 mg/kg. The PAFs are unlikely to pose any toxicological risk to birds (bobwhite quail, mallard ducks), fish (rainbow trout, carp), honeybees, earthworms, Daphnia, and algae. The observed LD50 (LC, EC) values are very favorable for all PAFs; only benalaxyl shows lower figures in respect to earthworm, Daphnia, and algae.
Questions And AnswerBack Directory
[Description]

Metalaxyl (chemical name: methyl N-(methoxyacetyl)-N-(2, 6-xylyl)-DL-alaninate) is an acylalanine fungicide of systemic function. It can be used for the treatment of pythium and phytophthora in many kinds of vegetables and peas. However, there are severe problem of drug resistance in current days. Metalaxyl exhibits strong activity against the mycelial growth of various sensitive fungi such as pythium splendens. The primary effect of metalaxyl seems to be related to its effect of interfering with the normal synthesis of RNA and DNA in sensitive fungi strains.
[References]

Kerkenaar, A. "On the antifungal mode of action of metalaxyl, an inhibitor of nucleic acid synthesis in Pythium splendens." Pesticide Biochemistry & Physiology 16.1(1981):1-13.
Fisher, David J., and A. L. Hayes. "Mode of action of the systemic fungicides furalaxyl, metalaxyl and ofurace." Pest Management Science13.3(2010):330-339.
Davidse, L. C., et al. "A comparison between the antifungal mode of action of metalaxyl, cyprofuram, benalaxyl and oxadixyl in phenylamide-sensitivity and -resistant strains. " Crop Protection 7.6(1988):347-355.
Metalaxyl showed the highest activity amongst the four fungicides against mycelial growth of sensitive strains on agar media.
Spectrum DetailBack Directory
[Spectrum Detail]

Metalaxyl(57837-19-1)MS
Metalaxyl(57837-19-1)1HNMR
Metalaxyl(57837-19-1)13CNMR
Metalaxyl(57837-19-1)IR1
Metalaxyl(57837-19-1)IR2
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

57837-19-1(sigmaaldrich)
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