| Identification | More | [Name]
Difenacoum | [CAS]
56073-07-5 | [Synonyms]
3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxy-2h-1-benzopyran-2-one
3-(3-Biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
DIFENACOUM
NEOSOREXA
RATAK
RIDAK
1’-biphenyl)-4-yl-1,2,3,4-tetrahydro-1-naphthalenyl)-4-hydroxy-2h-1-3-(3-(
2h-1-benzopyran-2-one,3-(3-(1,1’-biphenyl)-4-yl-1,2,3,4-tetrahydro-1-naphtha
3-(3-(4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxy-coumari
3-(3-(4-biphenylyl)-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin
difenakum
diphenacoum
lenyl)-4-hydroxy-
neosorexapp580
wba8107
difenacoum(bsi,e-iso,f-iso)
3-(3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthyl)-4-hydroxycoumarin difenacoum
2-Hydroxy-3-[3-(4-phenylphenyl)-1,2,3,4-tetrahydronaphthalen-1-yl]chromen-4-one | [EINECS(EC#)]
259-978-4 | [Molecular Formula]
C31H24O3 | [MDL Number]
MFCD01632770 | [Molecular Weight]
444.52 | [MOL File]
56073-07-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
T+,N | [Risk Statements ]
R28:Very Toxic if swallowed.
R48/25:Toxic: danger of serious damage to health by prolonged exposure if swallowed .
R50/53:Very Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S60:This material and/or its container must be disposed of as hazardous waste .
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
3027 | [WGK Germany ]
3 | [HazardClass ]
6.1(a) | [PackingGroup ]
I | [Hazardous Substances Data]
56073-07-5(Hazardous Substances Data) | [Toxicity]
LD50 orally in Wistar male, female rats (mg/kg): 1.8, 2.5; in male rabbits: 2.0 mg/kg; in dogs: 50 mg/kg; in cats: 100 mg/kg |
| Hazard Information | Back Directory | [Description]
Difenacoum, is also called 3-(3-biphenyl-4-yl-1,2,3,4-
tetrahydro-1-naphthyl)-4-hydroxycoumarin, consists of colorless crystals
which are insoluble in water, moderately to readily soluble
in acetone, chloroform, ethyl acetate, benzene.Difenacoum is synthesized by the condensation of 4-hydroxycoumarin and 3-biphenyl-4-yl-1,2,3,4-tetrahydro-1-naphthol (49). | [Uses]
Difenacoum is a 4-hydroxycouramin derivative. Difenacoum is a second generation anticoagulant rodenticide used against rodent pests such as rats and mice. | [Uses]
Pesticide. | [Definition]
ChEBI: Difenacoum is a ring assembly, a member of benzenes and a member of naphthalenes. | [Agricultural Uses]
Rodenticide: Difenacoum is an anticoagulant that is effective against
rats and mice, including warfarin-resistant strains. It is used
in agriculture and urban rodent control as ready-to-use baits. | [Trade name]
COMPO®; MATRAK®; NEOSOREXA®
PELLETS; NEOSOREXA PP580®; RASTOP®;
RATAK®; RATRICK®; SILO; SOREXA GEL; STORM | [Safety Profile]
A poison by ingestion and skincontact. When heated to decomposition it emits acridsmoke and irritating vapors. | [Toxicity evaluation]
Appearing in 1974, difenacoum was the first of the
new generation of anticoagulants to be commercialized for
the control of rodents resistant to warfarin and related
compounds (42). LD50 values (acute oral) for warfarinsusceptible
rodent strains are about a factor of 2 lower
than for warfarin-resistant strains. There is also a degree
of specificity. The compound is generally less toxic to
nontarget animals than to targets. A wide range of bait
types containing 0.005% difenacoum is available, including
meals, broken and whole grains, pellets, and wax blocks.
A 0.1% contact dust is no longer widely used. Resistance
to difenacoum was detected among a population of Norway
rats in the United Kingdom in 1978 (50). This remains a
problem of local importance but relatively low resistance
factors indicate that other behavioral factors also play a
significant role (51). Difenacoum resistance has also been
recorded in other European countries (39). |
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