| Identification | Back Directory | [Name]
BETA-NAADP SODIUM SALT | [CAS]
5502-96-5 | [Synonyms]
NAADP
NAADP tetrasodium sa
BETA-NAADP SODIUM SALT
NAADP tetrasodium salt
NICOTINATE ADENINE DINUCLEOTIDE PHOSPHATE
Nicotinic acid adenine dinucleotide phosphate
nicotinic acid adenine dinucleotide*phosphate sod
NAADP (NICOTINATE ADENINE DINUCLEOTIDE P HOSPHATE)
BETA-NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE
NICOTINIC ACID ADENINE DINUCLEOTIDE*PHOS PHATE SODIU
Nicotinicacidadeninedinucleotidephosphatetetrasodiumsalt
NICOTINIC ACID ADENINE DINUCLEOTIDE PHOSPHATE SODIUM SALT
5'-ester with 3-carboxy-1-b-D-ribofuranosylpyridinium innersalt
NAADP [Nicotinic acid adenine dinucleotide phosphate sodium salt]
Nicotinic acid adenine dinucleotide phosphate sodium salt >=92.5%
ADENOSINE 5'-(TRIHYDROGEN DIPHOSPHATE), 2'-(DIHYDROGEN PHOSPHATE), P'(5')-3-CARBOXY-1-BETA-D-RIBOFURANOSYLPYRIDINIUM INNER SALT | [Molecular Formula]
C21H28N7O17P3 | [MDL Number]
MFCD00274064 | [MOL File]
5502-96-5.mol | [Molecular Weight]
743.41 |
| Hazard Information | Back Directory | [Uses]
NAADP Tetrasodium Salt is a Ca2+ mobilizing agent. | [Uses]
Nicotinic acid adenine dinucleotide phosphate sodium salt has been used for agonist injection into unfertilized eggs and embryos. | [General Description]
NAADP induces Ca2+?release from the eggs of sea urchin, when injected into the cell. It can be enzymatically produced from nicotinamide adenine dinucleotide phosphate (β-NADP) with the help of ADP-ribosyl cyclase. | [Biological Activity]
Ca 2+ mobilizing agent. Initiates Ca 2+ release via type 1 ryanodine receptor (RyR1) activation. Also regulates Ca 2+ release from intracellular stores distinct from the endoplasmic reticulum (ER); displays affinity for two-pore channels (TPCs) which release Ca 2+ from acidic organelles. | [Biochem/physiol Actions]
Potent activator of intracellular Ca2+ release via an IP3 and cyclic ADP ribose-independent mechanism. | [in vivo]
NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3].
| Animal Model: | LPS/GalN induced liver injury mice model[3] | | Dosage: | 0.181 mg/kg | | Administration: | i.v. | | Result: | Promoted autophagosome formation in in hepatocytes.
Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.
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| [storage]
Store at -20°C |
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