| Identification | More | [Name]
N-NITROSODIETHYLAMINE | [CAS]
55-18-5 | [Synonyms]
DIETHYLNITROSAMINE
N,N-DIETHYLNITROSOAMINE
N-NITROSODIETHYLAMINE
1,1-Diethyl-2-oxohydrazine
DANA
DEN
den(mutagen)
DENA
Diaethylnitrosamin
Diethylamine, N-nitroso-
Diethylnitrosamide
Diethylnitrosoamine
diethyl-nitroso-amine
diethyl-n-nitrosamine
Ethylamine, N-nitrosodi-
N,N-Diethylnitrosamine
NDEA
n-ethyl-n-nitroso-ethanamin
N-Ethyl-N-nitrosoethanamine
n-ethyl-n-nitroso-ethanamine | [EINECS(EC#)]
200-226-1 | [Molecular Formula]
C4H10N2O | [MDL Number]
MFCD00013890 | [Molecular Weight]
102.14 | [MOL File]
55-18-5.mol |
| Chemical Properties | Back Directory | [Appearance]
yellow liquid | [Melting point ]
<25℃ | [Boiling point ]
177 °C (lit.) | [density ]
0.95 g/mL(lit.)
| [vapor pressure ]
1.7 mmHg at 20 °C | [refractive index ]
n20/D 1.437
| [storage temp. ]
2-8°C | [solubility ]
Chloroform (Soluble), Ethyl Acetate (Slightly), Methanol (Slightly) | [form ]
liquid
| [pka]
-3.14±0.70(Predicted) | [color ]
yellow
| [Odor]
Not available | [Stability:]
Stable, but light sensitive. Combustible. Incompatible with strong oxidizing agents, reducing agents. | [Water Solubility ]
106.2g/L(24 ºC) | [Merck ]
6636 | [BRN ]
1744991 | [CAS DataBase Reference]
55-18-5(CAS DataBase Reference) | [IARC]
2A (Vol. 17, Sup 7) 1987 | [EPA Substance Registry System]
N-Nitrosodiethylamine (55-18-5) |
| Safety Data | Back Directory | [Hazard Codes ]
T,F | [Risk Statements ]
R45:May cause cancer.
R22:Harmful if swallowed.
R39/23/24/25:Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed .
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed .
R11:Highly Flammable. | [Safety Statements ]
S53:Avoid exposure-obtain special instruction before use .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
S36/37:Wear suitable protective clothing and gloves .
S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
3
| [RTECS ]
IA3500000
| [HazardClass ]
6.1(b) | [PackingGroup ]
III | [HS Code ]
29299090 | [Safety Profile]
Confirmed carcinogen
with experimental carcinogenic,
neoplastigenic, and tumorigenic data. Poison
by ingestion, intravenous, intraperitoneal,
and subcutaneous routes. An experimental
teratogen. Other experimental reproductive
effects. Human mutation data reported. A
transplacental carcinogen. When heated to
decomposition it emits toxic fumes of NOx.
See also N-NITROSO COMPOUNDS and
AMINES. | [Hazardous Substances Data]
55-18-5(Hazardous Substances Data) | [Toxicity]
LD50 oral (rat) 280 mg/kg |
| Hazard Information | Back Directory | [General Description]
Clear slightly yellow liquid. Boiling point 175-177°C. Can reasonably be anticipated to be a carcinogen. Used as a gasoline and lubricant additive and as an antioxidant and stabilizer in plastics. | [Reactivity Profile]
N-NITROSODIETHYLAMINE(55-18-5) reacts with strong oxidizing agents. Incompatible with reducing agents. Can be hydrolyzed by hydrogen bromide in acetic acid . | [Air & Water Reactions]
Water soluble. | [Hazard]
Possible carcinogen; mutagen; neoplastigen; tumorigen; poison; teratogen. | [Health Hazard]
ACUTE/CHRONIC HAZARDS: When heated to decomposition this compound emits toxic fumes of nitrogen oxides. | [Potential Exposure]
An additive in gasoline and lubricants;
an antioxidant and stabilizer in plastics. Used in research.
Incompatibilities: Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Contact with reducing
agents may form hydrazine; hydrogen bromide. Light sensitive;
rapidly decomposes. | [Fire Hazard]
This chemical is combustible. | [First aid]
If this chemical gets into the eyes, remove any
contact lenses at once and irrigate immediately for at least
15 minutes, occasionally lifting upper and lower lids. Seek
medical attention immediately. If this chemical contacts the
skin, remove contaminated clothing and wash immediately
with soap and water. Seek medical attention immediately.
If this chemical has been inhaled, remove from exposure,
begin rescue breathing (using universal precautions, including
resuscitation mask) if breathing has stopped and CPR if
heart action has stopped. Transfer promptly to a medical
facility. When this chemical has been swallowed, get medical
attention. Give large quantities of water and induce
vomiting. Do not make an unconscious person vomit.
| [Shipping]
UN2810 Toxic liquids, organic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials, Technical
Name Required. UN3082 Environmentally hazardous
substances, liquid, n.o.s., Hazard Class: 9; Labels:
9-Miscellaneous hazardous material, Technical Name
Required. | [Incompatibilities]
An additive in gasoline and lubricants;
an antioxidant and stabilizer in plastics. Used in research.
Incompatibilities: Incompatible with oxidizers (chlorates,
nitrates, peroxides, permanganates, perchlorates, chlorine,
bromine, fluorine, etc.); contact may cause fires or explosions.
Keep away from alkaline materials, strong bases,
strong acids, oxoacids, epoxides. Contact with reducing
agents may form hydrazine; hydrogen bromide. Light sensitive;
rapidly decomposes. | [Chemical Properties]
N-Nitrosodiethylamine is a yellow liquid. | [Waste Disposal]
Consult with environmental
regulatory agencies for guidance on acceptable disposal
practices. Generators of waste containing this contaminant
(≥100 kg/mo) must conform with EPA regulations governing
storage, transportation, treatment, and waste disposal.
Under 40 CFR 261.5 small quantity generators of this
waste may qualify for partial exclusion from hazardous
waste regulations. | [Uses]
Gasoline and lubricant additive; antioxidant; stabilizer in plastics. | [Uses]
N,N-diethylnitrous Amide is a useful research reagent for organic synthesis. | [Uses]
N-Nitrosodiethylamine (DEN) is a widely occurring nitrosamine that is one of the most important environmental carcinogens primarily inducing tumors of liver. | [Definition]
ChEBI: A nitrosamine that is N-ethylethanamine substituted by a nitroso group at the N-atom. | [Flammability and Explosibility]
Volatilization during combustion produces hazardous vapors. Combustion products contain nitrogen oxides. | [Biochem/physiol Actions]
N-Nitrosodiethylamine (NDMA) is carcinogenic in all animal species tested. The main target organs are the nasal cavity, trachea, lung, esophagus and liver. NDMA is acted upon by the cytochrome P450 system resulting in the formation of carcinogenic methyldiazonium ion. However microbes like Pseudomonas metabolize NDMA into N-nitromethylamine (NTMA) and formaldehyde. | [Carcinogenicity]
N-Nitrosodiethylamine is reasonably anticipated to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in experimental animals. | [storage]
work with diethylnitrosamine should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and splash goggles should be worn at all times to prevent skin and eye contact. |
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