Identification | More | [Name]
2-Bromoethanol | [CAS]
540-51-2 | [Synonyms]
2-bromo-1-ethanol 2-BROMOETHANOL 2-Bromoethyl alcohol beta-Bromoethyl alcohol BROMOETHANOL-2 ETHYLENE BROMOHYDRIN 1-Bromo-2-ethanol 2-bromo-ethano 2-Hydroxyethyl bromide 2-hydroxyethylbromide bromoethanol -Bromoethylalcohol CH2BrCH2OH(trans) Glycol bromohydrin glycolbromohydrin Glycolbromo-hydrine 2-Bromo Ethenol 2-Bromorthanol 2-BROMOETHANOL, 1X1ML, TOL, 2000UG/ML 2-BROMOETHANOL, 1000MG, NEAT | [EINECS(EC#)]
208-748-1 | [Molecular Formula]
C2H5BrO | [MDL Number]
MFCD00002827 | [Molecular Weight]
124.96 | [MOL File]
540-51-2.mol |
Chemical Properties | Back Directory | [Appearance]
colourless liquid | [Melting point ]
-80 °C
| [Boiling point ]
56-57 °C/20 mmHg (lit.) | [density ]
1.763 g/mL at 25 °C(lit.)
| [vapor density ]
4.3 (vs air)
| [vapor pressure ]
2.4 mm Hg ( 20 °C)
| [refractive index ]
n20/D 1.492(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
1-5 g/100 mL at 19°C | [form ]
Liquid | [pka]
13.82±0.10(Predicted) | [color ]
Clear colorless to yellow | [Specific Gravity]
1.7629 (20/4℃) | [Stability:]
Stable, but probably light sensitive. Hygroscopic. Incompatible with strong oxidizing agents. Flammable. Forms an azeotrope with water. | [Water Solubility ]
1-5 g/100 mL at 19 ºC | [Sensitive ]
Light Sensitive | [Merck ]
14,3792 | [BRN ]
878140 | [InChIKey]
LDLCZOVUSADOIV-UHFFFAOYSA-N | [CAS DataBase Reference]
540-51-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanol, 2-bromo-(540-51-2) | [EPA Substance Registry System]
540-51-2(EPA Substance) |
Safety Data | Back Directory | [Hazard Codes ]
T,T+ | [Risk Statements ]
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed . R34:Causes burns. R40:Limited evidence of a carcinogenic effect. R36/37/38:Irritating to eyes, respiratory system and skin . R26/27/28:Very Toxic by inhalation, in contact with skin and if swallowed . R10:Flammable. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . S16:Keep away from sources of ignition-No smoking . | [RIDADR ]
UN 2922 8/PG 2
| [WGK Germany ]
3
| [RTECS ]
KJ8225000
| [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
II | [HS Code ]
29055900 | [Safety Profile]
Poison by
intraperitoneal route. Questionable
carcinogen with experimental neoplastigenic
and tumorigenic data. Mutation data
reported. When heated to decomposition it
emits toxic fumes of Br-. See also |
Questions And Answer | Back Directory | [Toxicity]
2-Bromoethanol can damage human body. The invasive ways of 2-bromoethanol include inhalation, ingestion and percutaneous absorption. 2-Bromoethanol has strong irritation to mucosa, upper respiratory tract, eyes and skin. Inhalation of 2-bromoethanol can cause death due to spasm, inflammation and edema of larynx and bronchus, chemical pneumonia and pulmonary edema. The manifestations of 2-bromoethanol poisoning include burning sensation, cough, wheezing, laryngitis, shortness of breath, headache, nausea and vomiting. |
Hazard Information | Back Directory | [General Description]
Colorless to dark brown liquid. Sweet burning taste. | [Reactivity Profile]
2-BROMOETHANOL(540-51-2) forms an azeotrope with water; hydrolysis of aqueous solutions is accelerated by heat, alkalis and acids. | [Air & Water Reactions]
Hygroscopic. Water soluble. | [Hazard]
Irritant to eyes and mucous membranes. | [Fire Hazard]
This compound is combustible. | [Description]
2-bromoethanol, a halogenated alipathic hydrocarbon, is a widely used industrial chemical. It is also a contaminant in food such as wheat and flour during treatment with ethylene oxide. 2-Bromoethanol was also found as a metabolite of 1,2-dibromoethane. A known carcinogen in experimental animals. 2-Bromoethanol is highly toxic in vivo and is a potent mutagen. Fatty acid conjugates of 2-bromoethanol that have been identified after 2-bromoethanol administration to rats may explain the long term 2-bromoethanol accumulation and retention in body tissues. Chronic exposure to 2-bromoethanol causes liver and kidney toxicity. 2- Bromoethanol also induces extensive lipid peroxidation in rat liver, kidney and testis slices and inhibits liver mitochondria respiration[1]. | [Chemical Properties]
colourless liquid | [Uses]
2-Bromoethanol is used in selective reduction of nitroarenes (PcFe(II)/NaBH4/2-bromoethanol catalyst system). | [Uses]
Ethylene bromohydrin is not used much forany commercial purpose. The risk of expo sure to this compound arises when ethyleneoxide reacts with hydrobromic acid. | [Health Hazard]
The vapors of ethylene bromohydrin are anirritant to the eyes and mucous membranes.It is corrosive to the skin. Ingestion of thiscompound can produce moderate to severetoxic effects. The target organs are the CNS,gastrointestinal tract, and liver. The lethaldose in mice by the intraperitoneal route was80 mg/kg. Ethylene bromohydrin manifested car cinogenicity in test animals. It caused tumorsin lungs and the gastrointestinal tract in micefrom intraperitoneal (150 mg/kg/8 weeks)and oral (43 mg/kg/80 weeks) dosages,respectively. It is a mutagen, positive to thehistidine reversion–Ames test. | [Synthesis]
Ethylene gas is washed and passed into an ice-cold solution of 7.2 g of bromine in 500 ml water. After complete absorption of the bromine, a fresh portion of 7.2 g, equal to the first, is added, with frequent and vigorous agitation, until a total weight of 200 g of bromine has reacted. The lower layer of ethylene dibromide, formed during the process, is separated, washed with water, and dried over sodium sulfate. Yield, 88 g. After neutralizing with the sodium carbonate and saturating the aqueous layer with sodium chloride, the 2-bromoethanol is extracted by shaking twice with 100 ml of ether, dried over sodium sulfate; the ether is removed by evaporation yielding 85 g of bulk of the residual liquid, which distils between 145-149° C. 54.4% of the bromine is converted into 2-bromoethanol and 37.5% into ethylene dibromide. The remainder is found as hydrobromic acid.
| [Waste Disposal]
Ethylene bromohydrin is mixed with a combustible solvent and burned in a chemicalincinerator. |
|
|