| Identification | Back Directory | [Name]
Glycyrrhizic acid ammonium salt | [CAS]
53956-04-0 | [Synonyms]
GLYCAMIL
ammoniate
glycyrram
Glycyrrhiz
Magnasweet
GLYCYRRHIZICAMMONIUM
AMMONIUMGLYCYRRHIZIN
ammoniumglycyrrhizate
GLYCYRRHIZIC ACID, NH4
Ammoniumglycynhizinato
AMMONIATEDGLYCERRHIZIN
AMMONIATED GLYCYRRHIZIN
GLYCYRRHIZIC ACID, NH4+
GLYCYRRHIZIN AMMONIACAL
GLYCYRRHIZIN, AMMONIATED
monoammoniumglycyrrhetat
AMMONIUM GLYCYRRHIZINATE
Ammonium Glyeyrrhizinate
Monoammoniumglycyrrhetate
monoammoniumglycyrrhizate
GLYCYRRHIZIN AMMONIUM SALT
GLYCYRRHIZIC ACID AMMONIUM
MONOAMMONIUM GLYCRRHIZINATE
Glycyrrhizine ammonium salt
MONOAMMONIUM GLYCYRRHIZINATE
Mono aMMoniuM glycrrnhizinate
MONOAMMONIATED GLYCYRRHIZINATE
glycyrrhizin monoammonium salt
GLYCYRRHIZINICACIDAMMONIUMSALT
GLYCYRRHIZIC ACID AMMONIUM SALT
Ammonium Glycyrrhizate (100 mg)
Glycyrrhizin Acid Ammonium Salt
MonoaMMoniuM 18β-glycyrrhizinate
AMMONIATED GLYCYRRHIZIN, NATURAL
GLYCERRHIZICACIDMONOAMMONIUMSALT
GLYCYRRHIZINATE MONOAMMONIUM SALT
GlycyrrhizinicAcidAmmoniumSalt,>95%
GLYCYRRHIZIC ACID MONOAMMONIUM SALT
GLYCYRRHIZIC ACID, AMMONIUM SALT(RG)
GLYCYRRHIZIC ACID AMMONIUM SALT FROM
Glycyrrhizic acid aMMoniuM salt EP/BP
Glycyrrhizic acid ammonium salt, >=73%
Glycyrrhizic acid MonoaMMoniuM salt, 98+%
GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.)
Glycyrrhizic acid aMMoniuM salt, froM Glycyrrhizae
Glycyrrhizic acid monoammonium salt trihydrate,98%
Glycyrrhizic acid MonoaMMoniuM salt trihydrate, 98% 25GR
MONOAMMONIUM GLYCYRRHIZINATE 95%
SODIUM GLYCYRRHIZINTE 95%
Glycyrrhizic acid, aMMoniuM salt, trihydrate / Glycyrrihizin
GLYCYRRHIZIN, AMMONIATED [GLYCYRRHIZINIC ACID, MONOAMMONIUM SALT]
Glycyrrhizic Acid Monoammonium Salt
Glycyrrhizin Monoammonium Salt
Glycyrrhizic acid ammonium salt from glycyrrhiza root (licorice)
Glycyrrhizic acid aMMoniuM salt froM glycyrrhiza root (licorice) >=70% (HPLC)
3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt
3-O-(2-O-BETA-D-GLUCOPYRANURONOSYL-ALPHA-D-GLUCOPYRANURONOSYL)-18BETA-GLYCYRRHETINIC ACID AMMONIUM SALT
3-O-(2-O-beta-D-Glucopyranuronosyl-alpha-D-glucopyranuronosyl)-18beta-g lycyrrhetinic acid ammonium salt
20β-Carboxy-11-oxo-30-noroleana-12-ene-3β-yl 2-O-(β-D-glucopyranuronosyl)-α-D-glucopyranosiduronic acid/ammonia,(1:x)
α-D-Glucopyranosiduronic acid, (3,20)-20-carboxy- 11-oxo-30-norolean-12-en-3-yl 2-O--D-glucopyranuronosyl-, monoammonium salt
a-D-Glucopyranosiduronic acid, (3b,20b)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-b-D-glucopyranuronosyl-, aMMoniuMsalt (1:1)
alpha-D-Glucopyranosiduronic acid, (3-beta,20-beta)-20-carboxy-11-oxo-30-norolean-12-en- 3-yl 2-O-beta-D-glucopyranuronosyl-, ammoniate
.alpha.-D-Glucopyranosiduronicacid,(3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl2-O-.beta.-D-glucopyranuronosyl-,monoammoniumsalt
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy-11-oxo-30-norolean-12-en-3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt
AMMONIUM 10-[6-CARBOXY-3-(6-CARBOXY-3,4,5-TRIHYDROXY-OXAN-2-YL)OXY-4,5-DIHYDROXY-OXAN-2-YL]OXY-2,4A,6A,6B,9,9,12A-HEPTAMETHYL-13-OXO-3,4,5,6,6A,7,8,8A,10,11,12,14B-DODECAHYDRO-1H-PICENE-2-CARBOXYLATE
3-O-(2-O-β-D-Glucopyranuronosyl-α-D-glucopyranuronosyl)-18β-glycyrrhetinic acid ammonium salt
Glycyrrhizin
Monoammonium Glycyrrhizinate Hydrate
Glycyrrhizic Acid Monoammonium Salt
Glycyrrhizin Monoammonium Salt
Glycyrrhiz
aMMoniuM (2S,3S,4S,5R,6S)-5-((2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxytetrahydro-2H-pyran-2-yloxy)-6-((3S,6aR,6bS,8aS,11S,12aR,14aR,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptaMethyl-14-oxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a,9,10,11,12,12a,14,14a,14b-icosahydrop
(2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxy-oxane-2-carboxylic acid
(2S,3S,4S,5R,6S)-6-[[(3S,4aS,6aR,6bS,8aR,11S,12aR,14aS,14bS)-11-carboxy-4,4,6a,6b,8a,11,14b-heptamethyl-14-oxo-2,3,4a,5,6,7,8,9,10,12,12a,14a-dodecahydro-1H-picen-3-yl]oxy]-5-[(2R,3R,4S,5S,6S)-6-carboxy-3,4,5-trihydroxy-oxan-2-yl]oxy-3,4-dihydroxyoxane-2-carboxylic acid azane | [EINECS(EC#)]
258-887-7 | [Molecular Formula]
C42H65NO16 | [MDL Number]
MFCD00167400 | [MOL File]
53956-04-0.mol | [Molecular Weight]
839.96 |
| Chemical Properties | Back Directory | [Appearance]
white to slightly yellow powder | [Melting point ]
>200°C (dec.) | [Boiling point ]
768.56°C (rough estimate) | [density ]
1.1846 (rough estimate) | [FEMA ]
2528 | GLYCYRRHIZIN, AMMONIATED (GLYCYRRHIZA SPP.) | [refractive index ]
49 ° (C=1.5, EtOH) | [storage temp. ]
2-8°C
| [solubility ]
Slightly soluble in water, very slightly soluble in anhydrous ethanol, practically insoluble in acetone. It dissolves in dilute solutions of acids and of alkali hydroxides. | [form ]
Powder or Crystals | [color ]
Yellow to yellow-green | [Odor]
bland | [optical activity]
[α]20/D +48±4°, c = 1% in ethanol: water (1:1) | [BRN ]
3897076 | [Stability:]
Hygroscopic | [InChIKey]
ILRKKHJEINIICQ-YDYGGSECSA-N | [LogP]
-0.9 | [Uses]
Monoammonium Glycyrrhizinate is a flavoring and sweetening agent obtained from licorice flavonoids. It has a slight licorice flavor and an intense and rounded sweetness. It is soluble in water, glycerin, and propylene glycol and has good thermal stability but can degrade under prolonged heating. It is stable over a ph of 3.5–9 but could precipitate below ph of 3.5. It can be used in beverages, desserts, confectionary products, soups, and dressings. | [CAS DataBase Reference]
53956-04-0 | [EPA Substance Registry System]
.alpha.-D-Glucopyranosiduronic acid, (3.beta.,20.beta.)-20-carboxy- 11-oxo-30-norolean-12-en- 3-yl 2-O-.beta.-D-glucopyranuronosyl-, monoammonium salt(53956-04-0) |
| Hazard Information | Back Directory | [Chemical Properties]
white to slightly yellow powder | [Uses]
Ammonium Glycyrrhizinate is used in the synthesis of polyion complex nanocarriers which may act as a template for the design of other negatively charged water-soluble drugs. Particularly for anti-infl
ammatory drugs with which Ammonium Glycyrrhizinate is associated. | [Uses]
anti-cancer agent | [Uses]
pharmaceutical excipient, GRAS, sweetener | [Description]
§ 184.1408(a)(1) Licorice (glycyrrhiza) root is the dried and ground
rhizome and root portions of Glycyrrhiza glabra or other species of
glycyrrhiza. Licorice extract is that portion of the licorice root that
is, after maceration, extracted by boiling water. The extract can be
further purified by filtration and by treatment with acids and ethyl
alcohol. Licorice extract is sold as a liquid paste ("block"), or spraydried
powder. (2) Ammoniated glycyrrhizin is prepared from the
water extract of licorice root by acid precipitation followed by neutralization
with dilute ammonia. Monoammonium glycyrrhizinate
(C42H61016NH45H2O ) is prepared from ammoniated glycyrrhizin by
solvent extraction and separation techniques. | [Definition]
ChEBI: Monoammonium glycyrrhizinate is an organic molecular entity. | [General Description]
Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate. | [Biochem/physiol Actions]
Biologically active constituent in the sweet root of Glycyrrhiza species (licorice). Antiviral. | [Anticancer Research]
Glycyrrhizin (GL) is a saponin-like compound that provides the main sweet flavourfor G. glabra (licorice), and it is commonly used in clinical treatment for itsoutstanding pharmacological action such as antitumour, anti-inflammatory andanti-oxidativeactions (Rebhun et al. 2015; Wu et al. 2015). Cai et al. (2017) triedto evaluate the anticancer properties of GA and GL against TNBC in combinationwith etoposide. | [target]
ROS | [Purification Methods]
Crystallise the ammonium salt from glacial acetic acid, then dissolve it in ethanolic ammonia and evaporate. The pentahydrate forms needles from 75% aqueous EtOH, m 212-217o. The free acid crystallises from glacial acetic acid. [Karrer et al. Helv Chim Acta 4 100 1921, Lithgoe & Tripett J Chem Soc 1983, 1987 1950, Beilstein 18 IV 5156.] |
| Safety Data | Back Directory | [RIDADR ]
UN 3077 9 / PGIII | [WGK Germany ]
2
| [RTECS ]
LZ6500000
| [F ]
3-10 | [HS Code ]
29389090 | [Safety Profile]
Moderately toxic by
intravenous route. An experimental
teratogen. Experimental reproductive
effects. Mutation data reported. When
heated to decomposition it emits toxic
fumes of NH3. |
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