| Identification | More | [Name]
4-AMINO-1-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE | [CAS]
5334-30-5 | [Synonyms]
1-PHENYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
4-AMINO-1-PHENYLPYRAZOLE[3,4-D]PYRIMIDINE
4-AMINO-1-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE
4-AMINO-7-PHENYLPYRAZOL[3,4-D]PYRIMIDINE
PP3
1-Phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-ylamine
4-AMINO-1-PHENYLPYRAZOLO[3,4-D]PYRIMIDINE: TECH., 85%
4-Amino-1-phenylpyrazolo3,4-düpyrimidine, tech. 85% | [Molecular Formula]
C11H9N5 | [MDL Number]
MFCD00022901 | [Molecular Weight]
211.22 | [MOL File]
5334-30-5.mol |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin .
R22:Harmful if swallowed. | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [Hazard Note ]
Irritant | [HS Code ]
29335995 |
| Hazard Information | Back Directory | [Chemical Properties]
Whit to Off-White Solid | [Uses]
Intermediate in the preparation of various enzymatic inhibitors | [Uses]
The Src family of non-receptor tyrosine kinases regulate cell adhesion, growth, and differentiation through activation of multiple intracellular signaling pathways. Normally inactive, Src kinases are transiently activated during mitosis and constitutively activated by abnormal mutations. Several small molecule inhibitors of this signaling pathway have been developed as a therapeuptic strategy to abate abnormal Src kinase activity. PP3 is an inactive analog of the Src tyrosine kinase inhibitors PP1 and PP2 . At concentrations as high as 10 μM, it does not prevent proliferation mediated by a stem cell factor/mast cell growth factor in hematopoietic and cancer cell lines.[Cayman Chemical] | [Definition]
ChEBI:1-phenyl-4-pyrazolo[3,4-d]pyrimidinamine is a ring assembly and a member of pyrazoles. | [Biological Activity]
Negative control for the src kinase inhibitor PP 2 (3-(4-chlorophenyl)1-(1,1-dimethylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine ). Inhibits EGFR kinase (IC 50 = 2.7 μ M). | [storage]
Store at -20°C |
|
| Company Name: |
Alfa Aesar
|
| Tel: |
400-6106006 |
| Website: |
http://chemicals.thermofisher.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
|