Identification | Back Directory | [Name]
Tetrahydroberberine | [CAS]
522-97-4 | [Synonyms]
THB CANADINE Nsc94918 l-Canadine DL-CANADINE AKOS 213-56 Xanthopuccine l-Xanthopuccine TETRAHYDROBERBERINE l-Tetrahydroberberine Berberine, tetrahydro- DL-TETRAHYDROBERBERINE Tetrahydroberberine, BR Tetrahydroberberine,THB Tetrahydroberberine, Canadine Tetrahydroberberine USP/EP/BP 9-Deoxy-16,17-dihydroberberine dl-Tetrahydroberberine 〔dl-Canadine〕 9,10-DiMethoxy-2,3-(Methylenedioxy)berbine Berbine, 9,10-dimethoxy-2,3-(methylenedioxy)- Tetrahydroberberine, 98%, from Coptis chinensis Franch. 5,8,13,13a-tetrahydro-9,10-dimethoxy-6H-benzo[g]benzo-1,3-dioxolo[5,6-a]quinolizine 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine 6H-Benzo[G]-1,3-benzodioxolo[5,6-A]quinolizine, 5,8,13,13A-tetrahydro-9,10-dimethoxy- 9,10-DIMETHOXY-5,8,13,13A-TETRAHYDRO-6H-[1,3]DIOXOLO[4,5-G]ISOQUINO[3,2-A]ISOQUINOLINE 5,8,13,13A-TETRAHYDRO-9,10-DIMETHOXY-6H-BENZO[G]-1,3-BENZODIOXOLO[5,6-ALPHA]QUINOLIZINE (13aR)-5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine Canadine, THB, 5,8,13,13a-Tetrahydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-alpha]quinolizine | [EINECS(EC#)]
208-338-2 | [Molecular Formula]
C20H21NO4 | [MDL Number]
MFCD00067284 | [MOL File]
522-97-4.mol | [Molecular Weight]
339.39 |
Chemical Properties | Back Directory | [Melting point ]
166.5 °C | [Boiling point ]
476.1±45.0 °C(Predicted) | [density ]
1.33±0.1 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO: >10 mg/mL, soluble
| [form ]
solid
| [pka]
6.53±0.20(Predicted) | [color ]
yellow
|
Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
22 | [Safety Statements ]
36 | [WGK Germany ]
3
| [Toxicity]
LD50 in mice (mg/kg): 940 orally; 790 s.c.; 100 i.v. (Sadritdinov, Sultanov) |
Hazard Information | Back Directory | [Uses]
Tetrahydroberberine is a protoberberine alkaloid which potently block functional KATP channels natively expressed on midbrain dopamine neurons. Tetrahydroberberine is used for treatment of degenerative diseases or conditions associated with KATP channel signaling.
| [Definition]
ChEBI: A berberine alkaloid that is 5,8,13,13a-tetrahydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline substituted by methoxy groups at positions 9 and 10. |
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