| Identification | More | [Name]
2-Methylpropanedioic acid | [CAS]
516-05-2 | [Synonyms]
2-METHYLPROPANEDIOIC ACID
METHYLMALONIC ACID
METHYLPROPANEDIOIC ACID
PROPANEDIOIC ACID, METHYL-
1,1-Ethanedicarboxylic acid
1,1-ethanedicarboxylicacid
2-Methylmalonic acid
2-methylmalonicacid
Isosuccinic acid
isosuccinicacid
Malonic acid, methyl-
methyl-malonicaci
Methyl (Ethoxy Methylene) Cyanoacetate
Methylmalonicacid,98%
Methylmalonic | [EINECS(EC#)]
208-219-5 | [Molecular Formula]
C4H6O4 | [MDL Number]
MFCD00002656 | [Molecular Weight]
118.09 | [MOL File]
516-05-2.mol |
| Chemical Properties | Back Directory | [Appearance]
white crystalline powder | [Melting point ]
128-130 °C (lit.) | [Boiling point ]
272.71°C (rough estimate) | [density ]
1.45
| [refractive index ]
1.4304 (estimate) | [Fp ]
2℃ | [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Crystalline Powder | [pka]
3.07, 5.76(at 25℃) | [color ]
White | [Specific Gravity]
1.455 | [PH]
3.23(1 mM solution);2.6(10 mM solution);2.05(100 mM solution) | [Water Solubility ]
soluble | [BRN ]
1756084 | [CAS DataBase Reference]
516-05-2(CAS DataBase Reference) | [NIST Chemistry Reference]
Methylmalonic acid(516-05-2) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 1648 3 / PGII | [WGK Germany ]
3
| [RTECS ]
OO1400000
| [HS Code ]
29171900 |
| Raw materials And Preparation Products | Back Directory | [Raw materials]
1,3-Di-tert-butyl2-methylpropanedioate-->3-ethoxy-2-Methyl-3-oxopropanoic acid-->Propanoic acid, 2-cyano--->Dimethyl methylmalonate-->DIETHYL MERCURY-->4-METHYL-PYRIDINE-2-CARBOXYLIC ACID-->Diethyl methylmalonate-->2-Chloropropionic acid | [Preparation Products]
cyclamen aldehyde-->5-hydroxy-3-Methyl-2(5H)-furanone-->2-Propenoic acid, 3-(2,6-dichlorophenyl)-2-methyl--->Benzenepropanoic acid, β-amino-α-methyl-, (αR,βS)-rel--->2H-Pyrano[3,2-c]pyridine-2,5(6H)-dione, 4-hydroxy-3,6,7-trimethyl- (9CI) |
| Hazard Information | Back Directory | [Chemical Properties]
white crystalline powder | [Uses]
2-Methylpropanedioic acid binds with coenzyme A to form methylmalonyl-CoA, also a metabolic intermediate transformed to succinic acid (SA) by a vitamin B12-dependent catalytic step, and is broadly used as a clinical biomarker of functional vitamin B12 status.
| [Definition]
ChEBI: A dicarboxylic acid that is malonic acid in which one of the methylene hydrogens is substituted by a methyl group. | [Biological Functions]
Methylmalonic acid is capable of diffusing out of cells in which it is being produced, so it may be detected in excess in the blood, CSF, and urine of patients with these various forms of the disease. | [General Description]
Methylmalonic acid is an indicator of vitamin B12 deficiency and methylmalonic acidemia. This Certified Spiking Solution? is suitable for use in preparation of calibrators or controls in clinical and diagnostic testing using GC/MS or LC/MS. | [storage]
Store at RT | [Purification Methods]
The acid crystallises as the hydrate from water. [Beilstein 2 IV 1932.] |
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