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ChemicalBook--->CAS DataBase List--->49562-28-9

49562-28-9

49562-28-9 Structure

49562-28-9 Structure
IdentificationBack Directory
[Name]

Fenofibrate
[CAS]

49562-28-9
[Synonyms]

lf-178
lipsin
sedufen
LIPYDIL
lipidax
lipifen
Lipirex
Liposit
Nolipax
Secalip
MeltDose
Lipantyl
lipoclar
lipofene
lipantil
LIPANTHYL
Elasterin
proctofene
procetofen
NSC 281319
Fenofibrite
Procetofene
FENOFIBRATE
Lipidil Supra
Fenofibrate API
Fenofibrate COS
Fenofibrate, >=99%
Fenofibrate (200 mg)
LABOTEST-BB LT00771982
isopropyl2-(4-(4-chlorobenzoyl)phenoxy)-2-methylpropionate
Isopropyl 2-[p-[p-chlorobenzoyl] phenoxy]-2-methylpropionate
isopropyl(4’-(p-chlorobenzoyl)-2-phenoxy-2-methyl)propionate
2-[4-[p-Chlorobenzoyl]]-2-methylpropionic acid isopropyl ester
propan-2-yl 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propanoate
ethyl 2-[4-(4-chlorophenyl)carbonylphenoxy]-2-methyl-propanoate
Propanoic acid, 2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-, ethyl ester
2-[p-(p-Chlorobenzoyl)phenoxy]-2-methylpropionic acid isopropyl ester
propan-2-yl 2-[4-(4-chlorophenyl)carbonylphenoxy]-2-methyl-propanoate
2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYLPROPANOIC ACID ISOPROPYL ESTER
2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-propionic acid isopropyl ester
2-(4-(4-chlorobenzoyl)phenoxy)-2-methyl-propanoicaci1-methylethylester
2-[4-(4-CHLOROBENZOYL)PHENOXYL-2-METHYLPROPANOIC ACID 1-METHYLETHYL ESTER
2-[4-(4-CHLOROBENZOYL)PHENOXY]-2-METHYL-PROPANOIC ACID, 1-METHYLETHYL ESTER
2-[4-[(4-chlorophenyl)-oxomethyl]phenoxy]-2-methylpropanoic acid ethyl ester
Fenofibrate,2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropanoic acid isopropyl ester
2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionic Acid Isopropyl Ester Isopropyl 2-[4-(4-Chlorobenzoyl)phenoxy]-2-methylpropionate
[EINECS(EC#)]

256-376-3
[Molecular Formula]

C20H21ClO4
[MDL Number]

MFCD00133314
[MOL File]

49562-28-9.mol
[Molecular Weight]

360.83
Chemical PropertiesBack Directory
[Appearance]

Crystalline Solid
[Melting point ]

80-810C
[Boiling point ]

469.8±35.0 °C(Predicted)
[density ]

1.177±0.06 g/cm3(Predicted)
[storage temp. ]

Store at RT
[solubility ]

Practically insoluble in water, very soluble in methylene chloride, slightly soluble in ethanol (96 per cent)
[form ]

powder
[color ]

off-white
[Water Solubility ]

0.8mg/L(25 ºC)
[Merck ]

14,3978
[BCS Class]

2
[InChI]

InChI=1S/C20H21ClO4/c1-13(2)24-19(23)20(3,4)25-17-11-7-15(8-12-17)18(22)14-5-9-16(21)10-6-14/h5-13H,1-4H3
[InChIKey]

YMTINGFKWWXKFG-UHFFFAOYSA-N
[SMILES]

C(OC(C)C)(=O)C(OC1=CC=C(C(=O)C2=CC=C(Cl)C=C2)C=C1)(C)C
[EPA Substance Registry System]

Propanoic acid, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methyl-, 1-methylethyl ester (49562-28-9)
Hazard InformationBack Directory
[Chemical Properties]

Crystalline Solid
[Usage]

antihyperlipidemic
[Usage]

Antilipemic. It is a lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expresion.
[Usage]

Cardiovascular disease
[Originator]

Lipantyl,Fournier,France,1975
[Uses]

antihyperlipidemic
[Uses]

Antilipemic. It is a lipid regulating drug. Increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expresion.
[Uses]

Cardiovascular disease
[Definition]

ChEBI: A chlorobenzophenone that is (4-chlorophenyl)(phenyl)methanone substituted by a [2-methyl-1-oxo-1-(propan-2-yloxy)propan-2-yl]oxy group at position 1 on the phenyl ring.
[Manufacturing Process]

(a) Preparation of p-(4-chlorobenzoyl)-phenoxyisobutyric acid: 1 mol of 4- hydroxy-4'-chlorobenzophenone is dissolved in anhydrous acetone and then 5 mols of powdered sodium hydroxide is added. The corresponding sodium phenoxide precipitates. Refluxing is effected, and then, 1.5 mols of CHCl3 diluted with anhydrous acetone is added and the resulting mixture is refluxed for 10 hours. After cooling, water is added, the acetone is evaporated, the aqueous phase is washed with ether and acidified and the organic phase is redissolved in ether and extracted into a solution of bicarbonate. The bicarbonate solution is than acidified to obtain the desired acid, having a melting point of 185°C, with a yield of 75%.
(b) Preparation of fenofibrate: 1 mol of the acid obtained is converted into its acid chloride using thionyl chloride (2.5 mols). 1 mol of the acid chloride is then condensed with 1.05 mol of isopropyl alcohol in the presence of 0.98 mol of pyridine in an inert solvent such as benzene.
Since traces of SO2 (which has a bad smell) may be obtained from the thionyl chloride, it is preferable to avoid this disadvantage by carrying out the esterification directly.
[Therapeutic Function]

Antihyperlipoproteinemic
[General Description]

Fenofibrate, 2-[4-(4-chlorobenzoyl)phenoxy]-2-methylpropanoic acid 1-methylethyl ester (Tricor),has structural features represented in clofibrate. The primarydifference involves the second aromatic ring. This imparts agreater lipophilic character than exists in clofibrate, resultingin a much more potent hypocholesterolemic and triglycerideloweringagent. Also, this structural modification results in alower dose requirement than with clofibrate or gemfibrozil.
[Biochem/physiol Actions]

Fenofibrate increases high density lipoprotein levels by reducing cholesteryl ester transfer protein expression. It is used in treating the condition of increased cholesterol levels in the blood, abnormal lipid levels in the body and also hypertriglyceridaemia. Fenofibrate is a lipid regulating drug and proliferator-activated receptor-α (PPARα) mediates its action. It decreases the plasma levels of fibrinogen and C-reactive protein. By this fenofibrate allows better flow-mediated dilatation and reduces the risk of atherosclerosis. Fenofibrate is also known to reduce uric acid levels.
[Clinical Use]

#N/A
[Drug interactions]

Potentially hazardous interactions with other drugs
Antibacterials: increased risk of myopathy with daptomycin - try to avoid concomitant use.
Anticoagulants: enhances effect of coumarins and phenindione; dose of anticoagulant should be reduced by up to 50% and readjusted by monitoring INR.
Antidiabetics: may improve glucose tolerance and have an additive effect with insulin or sulphonylureas.
Ciclosporin: ciclosporin levels appear to be unaffected; however, it is recommended that concomitant therapy should be avoided because of the possibility of elevated serum creatinine levels.
Colchicine: possible increased risk of myopathy.
Lipid-regulating drugs: increased risk of myopathy in combination with statins and ezetimibe (maximum 20 mg of rosuvastatin); increased risk of cholelithiasis and gallbladder disease with ezetimibe - avoid with ezetimibe.
[Metabolism]

After oral administration, fenofibrate is rapidly hydrolysed by esterases to the active metabolite fenofibric acid.
No unchanged fenofibrate can be detected in the plasma. Fenofibric acid is excreted mainly in the urine, mainly as the glucuronide conjugate, but also as a reduced form of fenofibric acid and its glucuronide; practically all the drug is eliminated from the body within 6 days
[storage]

Store at RT
Safety DataBack Directory
[Hazard Codes ]

Xn,Xi
[Risk Statements ]

22-36/37/38
[Safety Statements ]

36-26
[WGK Germany ]

3
[RTECS ]

UA2453400
[HS Code ]

29189900
[Hazardous Substances Data]

49562-28-9(Hazardous Substances Data)
[Toxicity]

LD50 in mice: 1600 mg/kg orally (Sornay)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Anisole-->4-Chlorobenzoyl chloride-->Thionyl chloride-->Isopropyl alcohol-->4-Chloro-4'-hydroxybenzophenone-->Sodium hydroxide-->Chloroform-->Acetone-->ISOPROPYL 2-(4-BROMOPHENOXY)-2-METHYLPROPANOATE-->Fenofibric acid-->Dihydro Fenofibrate-->9-Methylfluorene-9-carbonyl chloride-->Isopropyl 2-bromo-2-methylpropanoate-->1-Chloro-4-iodobenzene-->4-Chlorophenylboronic acid-->2-Bromopropane-->4-Bromochlorobenzene-->4-Chlorobenzaldehyde
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Fenofibrate(49562-28-9).msds
Spectrum DetailBack Directory
[Spectrum Detail]

Fenofibrate(49562-28-9)1HNMR
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