| Identification | More | [Name]
Isopropyl palmitate | [CAS]
142-91-6 | [Synonyms]
HEXADECANOIC ACID 1-METHYLETHYL ESTER
ISOPROPYL HEXADECANOATE
ISOPROPYL PALMITATE
PALMITIC ACID ISOPROPYL ESTER
1-Methylethyl ester1-methylethyl hexandecanoate
1-methylethyl hexadecanoate
1-Methylethylhexadecanoate
2-propyl hexadecanoate
Crodamol IPP
crodamolipp
Deltyl
Deltyl Prime
deltylprime
Emcol-IP
Emerest 2316
emerest2316
Estol 103
estol103
Hexadecanoic acid, isopropyl ester
Hexadecanoic acidisopropyl n-hexadecanoate | [EINECS(EC#)]
205-571-1 | [Molecular Formula]
C19H38O2 | [MDL Number]
MFCD00008993 | [Molecular Weight]
298.5 | [MOL File]
142-91-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
11-13 °C (lit.) | [Boiling point ]
160°C 2mm | [density ]
0.852 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.007Pa at 25℃ | [refractive index ]
n20/D 1.438(lit.)
| [Fp ]
>230 °F
| [storage temp. ]
2-8°C | [solubility ]
<0.001g/l | [form ]
neat | [color ]
Colourless | [Odor]
very sl. odor | [Water Solubility ]
Not miscible or difficult to mix with water. | [BRN ]
1786567 | [InChIKey]
XUGNVMKQXJXZCD-UHFFFAOYSA-N | [LogP]
8.16 | [Uses]
isopropyl palmitate is an emollient and moisturizer, it also acts as a binder and solvent. Similar to isopropyl myristate, it is produced from the combination of palmitic acid (coconut or palm oil) and isopropyl alcohol. enzymes are able to metabolize this ingredient and studies do not show allergic reactions or toxicity. Some sources indicate comedogenicity potential. | [CAS DataBase Reference]
142-91-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Isopropyl palmitate(142-91-6) | [EPA Substance Registry System]
142-91-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/38:Irritating to eyes and skin .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
-
| [RTECS ]
RT4900000
| [TSCA ]
Yes | [HS Code ]
29157090 | [Hazardous Substances Data]
142-91-6(Hazardous Substances Data) | [Toxicity]
mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689, |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless liquid | [Chemical Properties]
Isopropyl palmitate is a clear, colorless to pale yellow-colored,
practically odorless viscous liquid that solidifies at less than 16°C. | [Definition]
ChEBI: A fatty acid ester obtained by the formal condensation of carboxy group of palmitic acid with propan-2-ol. Metabolite observed in cancer metabolism. | [Production Methods]
Isopropyl palmitate is prepared by the reaction of palmitic acid with
propan-2-ol in the presence of an acid catalyst. A high-purity
material is also commercially available, which is produced by
enzymatic esterification at low temperatures. | [General Description]
Isopropyl palmitate is an analog of isopropyl myristate and an aliphatic ester used as a flavoring ingredient in food industry. It is one of the volatile compounds found in Psidium salutare fruits and boiled buckwheat flour.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. | [Pharmaceutical Applications]
Isopropyl palmitate is a nongreasy emollient with good spreading
characteristics, used in topical pharmaceutical formulations and
cosmetics such as: bath oils; creams; lotions; make-up; hair care
products; deodorants; lip products; suntan preparations; and
pressed powders.
Isopropyl palmitate is an established penetration enhancer for
transdermal systems. It has also been used in controlled-release
percutaneous films.
Table I: Uses of isopropyl palmitate | [Side effects]
Side effects for the skin: If overused, isopropyl palmitate may cause acne, blackheads, whiteheads, and clogged pores. Depending on the content of the ingredients in the product, the skin may experience some irritation. If isopropyl palmitate is used without dilution, it may cause comedoles. People with oily skin should also avoid isopropyl palmitate.
Side effects for hair: Excessive use of products containing isopropyl palmitate on hair can make hair look untidy, oily, and untidy due to excessive moisture in the hair. When there is an open wound on the scalp, isopropyl palmitate should also be avoided. | [Safety]
Isopropyl palmitate is widely used in cosmetics and topical
pharmaceutical formulations, and is generally regarded as a
relatively nontoxic and nonirritant material.
LD50 (mouse, IP): 0.1 g/kg | [storage]
Isopropyl palmitate is resistant to oxidation and hydrolysis, and
does not become rancid. It should be stored in a well-closed
container, above 16°C, and protected from light. | [Regulatory Status]
Included in the FDA Inactive Ingredients Database (topical and
transdermal preparations). Used in nonparenteral medicines
licensed in the UK. Included in the Canadian List of Acceptable
Non-medicinal Ingredients. |
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