| Identification | Back Directory | [Name]
Pinostrobin | [CAS]
480-37-5 | [Synonyms]
Pistrobin
Pinostobin
PINOSTROBIN
Pinostrombin
5-Hydroxy-7-methoxyflavanone
PINOCEMBRIN-7-METHYLETHER(RG)(PLEASE CALL)
5-Hydroxy-7-methoxy-2-phenyl-chroman-4-one
(S)-2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-4-benzopyrone
2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
2-Phenyl-5-hydroxy-7-methoxy-2,3-dihydro-4H-1-benzopyran-4-one
(S)-2,3-DIHYDRO-5-HYDROXY-7-METHOXY-2-PHENYL-4H-1-BENZOPYRAN-4-ONE
(2S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
4H-1-Benzopyran-4-one, 2,3-dihydro-5-hydroxy-7-methoxy-2-phenyl-, (2S)-
Pinostrobin,(S)-2,3-Dihydro-5-hydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one | [EINECS(EC#)]
207-548-1 | [Molecular Formula]
C16H14O4 | [MDL Number]
MFCD06858342 | [MOL File]
480-37-5.mol | [Molecular Weight]
270.28 |
| Chemical Properties | Back Directory | [Melting point ]
100°C | [Boiling point ]
494.9±45.0 °C(Predicted) | [density ]
1.284±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
DMF: 20 mg/ml; DMF:PBS (pH 7.2)(1:3): 0.25 mg/ml; DMSO: 12 mg/ml | [form ]
A crystalline solid | [pka]
7.40±0.40(Predicted) | [color ]
White to yellow | [LogP]
3.591 (est) |
| Hazard Information | Back Directory | [Description]
Pinostrobin is a flavonoid with diverse biological activities, including antioxidant, anti-inflammatory, and anticancer properties.1 It induces quinone reductase (QR) in murine hepatoma cells with a QR doubling concentration of 500 nM.2 Pinostrobin inhibits TNF-α and IL-1β production in RAW 264.7 macrophages (IC50s = 17.28 and 23.5 μM, respectively) and in LPS-stimulated rats (48.6 and 55% reduction, respectively).3 Pinostrobin also shows selective cytotoxicity for CCRF-CEM leukemia cells (IC50 = 10.2 μM) in a panel of eight cancer cell lines (IC50s = >30 μM).4 | [Uses]
Pinostrombin is a useful research chemical that can be used for chemical fingerprinting, isolating, and characterizing of polyphenol compounds. It can also be used as a potential compound for TMPRSS2 inhibition for Covid-19 therapy. | [Definition]
ChEBI: A monohydroxyflavanone that is (2S)-flavanone substituted by a hydroxy group at position 5 and a methoxy group at position 7 respectively. |
|
|