| Identification | More | [Name]
Glycocholic acid | [CAS]
475-31-0 | [Synonyms]
3a,7a,12a-trihydroxy-5b-cholan-24-oic acid n-(carboxymethyl)amide
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-[CARBOXYMETHYL]AMIDE
3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-5BETA-CHOLAN-24-OIC ACID N-(CARBOXYMETHYL) AMIDE, HYDRATE
5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL 24-N-(CARBOXYMETHYL)-AMIDE
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL N-(CARBOXYMETHYL)-AMIDE
cholylglycine
CHOLYLGLYCINE HYDRATE
GLYCOCHOLIC
GLYCOCHOLIC ACID
GLYCOCHOLIC ACID HYDRATE
N-[3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL]GLYCINE
N-(3ALPHA,7ALPHA,12ALPHA-TRIHYDROXY-24-OXOCHOLAN-24-YL)-GLYCINE HYDRATE
n-(3-alpha,7-alpha,12-alpha-trihydroxycholan-24-oyl)glycine
[(3,7,12-Trihydroxy-24-oxocholan-24-yl)amino]acetic acid
Glycine, N-[(3alpha,5beta,7alpha,12alpha)-3,7,12-trihydroxy-24-oxocholan-24-yl]-
N-((3,5,7,12)-3,7,12-Trihydroxy-24-oxocholan-24-yl)glycine
N-Cholylglycine
glycocholic acid free acid
GLYCOCHOLIC ACID HYDRAT
Clycocholic acid | [EINECS(EC#)]
207-494-9 | [Molecular Formula]
C26H43NO6 | [MDL Number]
MFCD06408004 | [Molecular Weight]
465.62 | [MOL File]
475-31-0.mol |
| Chemical Properties | Back Directory | [Melting point ]
128°C | [Boiling point ]
568.76°C (rough estimate) | [density ]
1.1336 (rough estimate) | [refractive index ]
1.6000 (estimate) | [storage temp. ]
Refrigerator | [solubility ]
methanol: 0.1 g/mL, clear, colorless
| [form ]
Solid | [pka]
4.4(at 25℃) | [color ]
White to Off-White | [Water Solubility ]
329.9mg/L(20 ºC) | [Merck ]
13,4507 | [Stability:]
Hygroscopic | [InChIKey]
RFDAIACWWDREDC-NSPZZGDONA-N | [LogP]
1.650 | [CAS DataBase Reference]
475-31-0(CAS DataBase Reference) | [NIST Chemistry Reference]
Glycocholic acid(475-31-0) |
| Safety Data | Back Directory | [Hazard Codes ]
N | [Risk Statements ]
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment . | [Safety Statements ]
S61:Avoid release to the environment. Refer to special instructions safety data sheet . | [RIDADR ]
UN 3077 9/PG 3
| [WGK Germany ]
3
|
| Hazard Information | Back Directory | [Description]
N-Cholylglycine. Bile salt, conjugate of cholate and glycine, usually
as the sodium salt. It acts as a detergent to solubilize fats for
absorption and is itself absorbed. It is used as a cholagogue and
choleretic. | [Chemical Properties]
Off-White Solid | [Uses]
Labelled Glycocholic Acid. The product of conjugation of cholic acid with glycine; chief ingredient of the bile of herbivorous animals. In the weakly alkaline bile fluid glycocholic acid exists as the sodium salt. | [Definition]
ChEBI: A bile acid glycine conjugate having cholic acid as the bile acid component. | [Purification Methods]
Glycocholic acid crystallises from hot water as the sesquihydrate. Dry it at 110o in vacuo. An analytical sample is prepared by suspending the acid (4g) in H2O (400mL) at ~20o, heating to boiling with slow stirring, filtering hot and allowing to cool to ~20o. The acid is filtered off, washed with H2O, dried in air, recrystallised from 5% aqueous EtOH, washed well and dried over P2O5 in a moderate vacuum to constant weight. Recrystallisation from EtOH/EtOAc, and drying, gave the anhydrous acid. [Cortese & Bauman J Am Chem Soc 57 1393 1935, Bergstrom & Norman Acta Chem Scand 7 1126 1953, Beilstein 10 IV 2077.] |
|
|