| Identification | Back Directory | [Name]
Cinobufagin | [CAS]
470-37-1 | [Synonyms]
FEMA 2288
AKOS 233-01
CINOBUFAGIN
16-beta)-bet
cinobufagine
AKOS B004228
CINOBUFAGIN(P)
Cinobufagin std.
CINOBUFAGIN95%,99%
RARECHEM BK HC T302
3-STYRYLACRYLIC ACID
3-PHENYLACRYLIC ACID
CINNAMIC ACID, TRANS-
TRANS-CINNAMYLIC ACID
cinobufagin venom toad
BETA-PHENYLACRYLIC ACID
Cinobufogenin，Cinobufagin
TRANS-3-PHENYLPROPENOIC ACID
TRANS-3-BENZENEPROPENOIC ACID
2-PROPENOIC ACID, 3-PHENYL-, (2E)-
16β-Acetoxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
5b,20(22)-Bufadienolide-3b,16b-diol-14,15b-epoxy 16-acetate
5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate
16β-Acetyloxy-14,15β-epoxy-3β-hydroxy-5β-bufa-20,22-dienolide
14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
5BETA,20[22]-BUFADIENOLIDE-3BETA,16BETA-DIOL-14,15BETA-EPOXY 16-ACETATE
22-dienolide,16-(acetyloxy)-14,15-epoxy-3-hydroxy-,(3-beta,5-beta,15-bufa-2
14,15BETA-EPOXY-3BETA,16BETA-DIHYDROXY-5BETA,20[22]-BUFADIENOLIDE 16-ACETATE
5β,20(22)-Bufadienolide-3β,16β-diol-14,15β-epoxy 16-acetate, 14,15β-Epoxy-3β,16β-dihydroxy-5β,20(22)-bufadienolide 16-acetate
5-((1R,2R,2aR,3aS,3bR,5aR,7S,9aS,9bS,11aR)-2-Acetyl-7-hydroxy-9a,11a-diMethylhexadecahydronaphtho[1',2':6,7]indeno[1,7a-b]oxiren-1-yl)-2H-pyran-2-one | [EINECS(EC#)]
205-398-1 | [Molecular Formula]
C26H34O6 | [MDL Number]
MFCD00004369 | [MOL File]
470-37-1.mol | [Molecular Weight]
442.55 |
| Chemical Properties | Back Directory | [Melting point ]
133 °C(lit.)
| [Boiling point ]
300 °C(lit.)
| [density ]
1.261 g/cm3 | [Fp ]
>230 °F
| [storage temp. ]
2-8°C
| [solubility ]
DMF: 10 mg/ml; DMSO: 10 mg/ml; DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml | [form ]
powder to crystal | [pka]
15.10±0.70(Predicted) | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Uses]
Cinobufagine is a major component of cinobufacini (huachansu), is an important cardenolidal steroid. Cinobufagine was shown to exhibit potent anti-cancer effects. | [Definition]
ChEBI: Cinobufagin is a steroid lactone. It is functionally related to a bufanolide. |
| Questions And Answer | Back Directory | [Description]
Cinobufagin is a cardiotoxic bufanolide steroid secreted by the Asiatic toad Bufo gargarizans, having similar effects to digitalis and used in traditional Chinese medicine. It has potential antineoplastic activity and now is widely used in clinical practice, especially in anti-liver cancer. It has benn found to suppress cancer cell proliferation and cause apoptosis in cancer cells via a sequence of apoptotic modulators, including mitochondrial Bax and cytosolic chromosome c, and caspases 3, 8, and 9.
| [References]
1. https://en.wikipedia.org/wiki/Cinobufagin
2. https://www.cancer.gov/publications/dictionaries/cancer-drug?cdrid=689412
3. http://www.yourdictionary.com/cinobufagin
4. https://www.medchemexpress.com/cinobufagin.html
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