| Identification | Back Directory | [Name]
N3-PEG1-CH2CH2NH2 | [CAS]
464190-91-8 | [Synonyms]
N3-PEG1-NH2
Azido-PEG1-Amine
Amino-PEG2-azide
N3-PEG1-CH2CH2NH2
2-(2-Azidoethoxy)ethanamine
2-(2-azidoethoxy)ethan-1-amine
Azido-PEG1-amine,2-(2-azidoethoxy)ethanamine | [Molecular Formula]
C4H11N4O+ | [MDL Number]
MFCD23726611 | [MOL File]
464190-91-8.mol | [Molecular Weight]
131.156 |
| Chemical Properties | Back Directory | [storage temp. ]
Amber Vial, Refrigerator, Under inert atmosphere | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Oil | [color ]
Colourless to Off-White |
| Hazard Information | Back Directory | [Description]
Azido-PEG1-amine is a heterobifunctional linker containing an amino(NH2)and an azide (N3) group. The amino group is reactive with carboxylic acids, activated NHS esters,. The azide(N3) group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. | [Uses]
Azido-PEG1-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Azido-PEG1-amine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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