| Identification | Back Directory | [Name]
Bromo-PEG5-Azide | [CAS]
1402411-90-8 | [Synonyms]
Br-PEG5-N3
Azido-PEG5-Br
Bromo-PEG5-Azide
N3-PEG5-CH2CH2Br | [Molecular Formula]
C12H25BrN3O5+ | [MDL Number]
MFCD26127825 | [MOL File]
1402411-90-8.mol | [Molecular Weight]
371.248 |
| Hazard Information | Back Directory | [Description]
Bromo-PEG5-azide contain a bromide group and a terminal azide. The bromide (Br) is a very good leaving group for nucleophilic reactions. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. PEG5 spacer increases solubility in aqueous media. | [Uses]
Bromo-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromo-PEG5-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups. | [IC 50]
PEGs | [References]
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
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