| Identification | More | [Name]
2-Fluoro-5-nitropyridine | [CAS]
456-24-6 | [Synonyms]
2-FLUORO-5-NITROPYRIDINE
6-FLUORO-3-NITROPYRIDINE | [EINECS(EC#)]
207-260-6 | [Molecular Formula]
C5H3FN2O2 | [MDL Number]
MFCD03095059 | [Molecular Weight]
142.09 | [MOL File]
456-24-6.mol |
| Chemical Properties | Back Directory | [Melting point ]
142-144 C | [Boiling point ]
86-87℃/7mm lit. | [density ]
4,64g/cm | [refractive index ]
1.5250 | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
Liquid | [pka]
-4.47±0.10(Predicted) | [color ]
Colorless to pale yellow | [Water Solubility ]
Slightly soluble in water. | [Sensitive ]
Moisture Sensitive | [CAS DataBase Reference]
456-24-6(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed . | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
UN 1549 |
| Hazard Information | Back Directory | [Uses]
It is used in the preparation of nitropyridines by nitration of pyridines with nitric acid. | [Synthesis]
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 ??C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 ?á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%). |
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