| Identification | More | [Name]
Thiazolidine-4-carboxylic acid | [CAS]
444-27-9 | [Synonyms]
1,3-THIAZOLIDINE-4-CARBOXYLIC ACID
AKOS BBS-00007512
AURORA 619
THIAZOLIDINE-4-CARBOXYLIC ACID
THIOPROLINE
TIMONACIC
4-carboxythiazolidine
4-thiazolidinecarboxylicacid
acidethiazolidine-4-carboxylique
gamma-thiaproline
hepalidine
heparegene
norgamem
nsc25855
t-4ca
usafa-3701
Thioproline Crystalline
L-Hepalidine
4-THIOZOLIDINECARBOXYLICACID
1-THIAZOLIDINE-4-CARBOXYLICACID | [EINECS(EC#)]
207-146-6 | [Molecular Formula]
C4H7NO2S | [MDL Number]
MFCD00128958 | [Molecular Weight]
133.17 | [MOL File]
444-27-9.mol |
| Chemical Properties | Back Directory | [Melting point ]
196.5°C | [Boiling point ]
350.3±37.0 °C(Predicted) | [density ]
1.226 (estimate) | [refractive index ]
1.5480 (estimate) | [storage temp. ]
Room Temperature | [solubility ]
DMSO (Slightly), Water (Slightly) | [form ]
solid | [pka]
2.09±0.20(Predicted) | [color ]
White to off-white | [Water Solubility ]
29.3g/L(21 ºC) | [CAS DataBase Reference]
444-27-9(CAS DataBase Reference) | [EPA Substance Registry System]
444-27-9(EPA Substance) |
| Hazard Information | Back Directory | [Originator]
Hepaldine,Riker,France,1964 | [Uses]
hepatoprotectant | [Uses]
Timonacic is a derivative of Proline (P756050), a cyclic nonessential amino acid. Timonacic is a research molecule of interest with potential antineoplastic activities by acting on the cell membrane of tumour cells and causing reverse transformation to normal cells. | [Definition]
ChEBI: A sulfur-containing amino acid that is proline in which the methylene group at position 4 is replaced by a sulfur atom. | [Manufacturing Process]
Cysteine is first dissolved in distilled water which has been freed of oxygen by
boiling. Formaldehyde of 30% (w/v) concentration is added while stirring and
the temperature of the mixture rises, while the thiazolidine carboxylic acid
begins crystallizing. The stirring is continued for 2 hours after which ethyl
alcohol of 95% (w/v) concentration is added to induce further crystallization.
The mixture is left to stand for 24 hours at 4°C. The mixture is then filtered
with retention of a crude product, which is purified by recrystallization from
boiling distilled water. The crystals are then dried at about 40°C. The free acid
is then converted to the sodium salt with NaOH. | [Therapeutic Function]
Hepatoprotectant, Choleretic |
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