| Identification | More | [Name]
4-Morpholineethanesulfonic acid | [CAS]
4432-31-9 | [Synonyms]
2-(4-MORPHOLINO)ETHANESULFONIC ACID
2-MORPHOLINOETHANESULFONIC ACID
2-(N-MORPHOLINO)ETHANESULFONIC ACID
2-(N-MORPHOLINO)ETHANESULPHONIC ACID
4-MORPHOLINEETHANESULFONIC ACID
4-MORPHOLINOETHANESULFONIC ACID
MES
MES BUFFERED SALINE
MORPHOLINOETHANE SULFONIC ACID
TIMTEC-BB SBB009135
mes(bufferingagent)
morpholinoethanesulfonic
2-(4-Morpholino)ethanesulphonic acid
MES 2-(N-Morpholino)ethanesulfonic acid
mes free acid hydrate
mes free acid molecular biology
mes free acid plant cell culture tested
MES, Free Acid, ULTROL Grade
MES, Molecular Biology Grade 2-(N-Morpholino)ethanesulfonic acid, Molecular Biology Grade
2-morpholinoethanesulphonic acid | [EINECS(EC#)]
224-632-3 | [Molecular Formula]
C6H13NO4S | [MDL Number]
MFCD00006181 | [Molecular Weight]
195.24 | [MOL File]
4432-31-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White/clear crystalline powder | [Melting point ]
>300 °C(lit.)
| [Boiling point ]
102°C | [density ]
1.208 (estimate) | [refractive index ]
1.5500 (estimate) | [storage temp. ]
Store at RT. | [solubility ]
H2O: 0.5 M at 20 °C, clear
| [form ]
Powder | [pka]
pKa at 0.1M ionic: 0°, 6.38; 20°, 6.15; 37°, 5.98; pKa1 1.99; pKa2 6.21; pKa/°C -0.011 | [color ]
White | [PH]
2.5-4.0 (25℃ in neat) | [PH Range]
5.5 - 6.7 | [Stability:]
Stable. Incompatible with strong oxidizing agents. | [Water Solubility ]
185.2g/L at 20℃ | [λmax]
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01 | [Merck ]
13,5929 | [BRN ]
6350956 | [InChIKey]
SXGZJKUKBWWHRA-UHFFFAOYSA-N | [LogP]
-2.2 at 20℃ | [CAS DataBase Reference]
4432-31-9(CAS DataBase Reference) | [EPA Substance Registry System]
4432-31-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S24/25:Avoid contact with skin and eyes .
S22:Do not breathe dust . | [WGK Germany ]
1
| [RTECS ]
QE9104530
| [HS Code ]
29349990 |
| Questions And Answer | Back Directory | [Application]
4-Morpholineethanesulfonic acid (MES) is one of the good′s buffers, and the most extensively application is biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring and it does not form complexes with the majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. MES has been also used as a component of the elution buffer used to elute plasma from α2-macroglobulin affinity column. It has been used as an activation buffer during antibody conjugation to microparticles and it has been used in the functionalization of microchannels during the creation of microfluidic-integrated surface plasmon resonance (SPR) platform for pathogen detection.
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| Hazard Information | Back Directory | [Chemical Properties]
White/clear crystalline powder | [Uses]
Biological buffer. | [Definition]
ChEBI: 2-(N-morpholino)ethanesulfonic acid is a Good's buffer substance, pKa = 6.15 at 20 ℃. It is an organosulfonic acid and a MES. It is a conjugate acid of a 2-(N-morpholino)ethanesulfonate. It is a tautomer of a 2-(N-morpholiniumyl)ethanesulfonate. | [General Description]
MES is one of the Good′s buffers, the most extensively used biological buffers. MES is a zwitterionic N-substituted aminosulfonic acid with a morpholinic ring. It does not form complexes with majority of the metals used in environmental and biological studies. It is easily soluble in water and has minimum lipid solubility, making it impermeable to membranes. | [Flammability and Explosibility]
Notclassified | [storage]
Store at RT | [Purification Methods]
Crystallise MES from hot EtOH containing a little water. The picrate crystallises from EtOH and has m 178.8-182o. [Malkiel & Mason J Org Chem 8 199 1943, Beilstein 27 III/IV 370.] |
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