| Identification | More | [Name]
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID | [CAS]
42438-90-4 | [Synonyms]
TCR
TNCA
L -CarL
H-TPI-OH
H-THNH(3)-OH
Lycoperodine 1
TNCA >=98% (HPLC)
RARECHEM BK PT 0088
CYCLOMETHYLTRYPTOPHAN
4-Tetrahydro-9H-pyrido[3
4-b]indole-3-carboxylic acid
L-TRYPTOLINE-3-CARBOXYLIC ACID
4-Tetrahydro-b-carboline-3-carboxylic acid
L-1,2,3,4-TETRAHYDRONORHARMAN-3-CARBOXYLIC ACID
1,2,3,4-TETRAHYDRONORHARMAN-L-3-CARBOXYLIC ACID
L-1,2,3,4-tetrahydronorharmane-3-carboxylic acid
9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
L-1,2,3,4-Tetrahydro-β-carbolin-3-carboxylic acid
(S)-1,2,3,4-Tetrahydronorharmane-3-carboxylic acid
L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carb
L-2,3,4-TETRAHYDRO-BETA-CARBOLINE-3-CARBOXYLIC ACID
2,3,4,9-Tetrahydro-1H-β-carboline-3-carboxylic acid
(S)-1,2,3,4-Tetrahydro-β-carboline-3-carboxylic acid
(3S)-1,2,3,4-Tetrahydro-β-carboline-3α-carboxylic acid
(3S)-1,3,4,9-tetrahydro-$b-carbolin-2-ium-3-carboxylate
(3S)-2,3,4,9-tetrahydro-1H-$b-carboline-3-carboxylic acid
(3S)-1H,2H,3H,4H,9H-pyrido[3,4-b]indole-3-carboxylic acid
(3S)-2,3,4,9-Tetrahydro-1H-beta-carboline-3-carboxylic acid
(3S)-1,3,4,9-tetrahydropyrido[5,4-b]indol-2-ium-3-carboxylate
L-1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
(S)-2,3,4,9-TETRAHYDRO-1H-PYRIDO[3,4-B]INDOLE-3-CARBOXYLIC ACID
(3S)-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid
(3S)-2,3,4,9-tetrahydro-1H-pyrido[5,4-b]indole-3-carboxylic acid
(3S)-2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-3α-carboxylic acid
1H-Pyrido[3,4-b]indole-3-carboxylic acid, 2,3,4,9-tetrahydro-, (3S)-
L-1,2,3,4-Tetrahydro-9H-pyrido[3,4-b]indole-3-carboxylic acid, L-Tryptoline-3-carboxylic acid, H-Tpi-OH, L-1,2,3,4-Tetrahydro-b-carboline-3-carboxylic acid | [Molecular Formula]
C12H12N2O2 | [MDL Number]
MFCD00272641 | [Molecular Weight]
216.24 | [MOL File]
42438-90-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
289 °C (dec.)(lit.) | [Boiling point ]
485.0±45.0 °C(Predicted) | [density ]
1.377±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C | [solubility ]
soluble1.5mg/mL, clear (Solvent: 0.1N HCl:DMSO (1:1); warmed) | [form ]
powder | [pka]
2.28±0.20(Predicted) | [color ]
white to beige | [optical activity]
[α]/D -57 to -67°, c = 1 (in MeOH:1N HCl (1:1)) | [InChIKey]
FSNCEEGOMTYXKY-JTQLQIEISA-N | [CAS DataBase Reference]
42438-90-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [HazardClass ]
IRRITANT |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Biochem/physiol Actions]
TNCA is a tryptophan derivative that binds the parathyroid Ca2+-sensing receptor (CaSR) extracellular domain (ECD) hinge region between two globular subdomains and acts as a high-affinity CaSR ligand (CaSRL) with co-agonist activity. TNCA is shown to potentiate both Mg++- and Ca++-evoked cellular calcium response (0.1-0.5 mM), as well as Mg++-evoked cellular ERK1/2 phosphorylation in CaSR-expressing HEK293 cells (0.5 mM). AC-265347 (Cat. No. SML0129), on the other hand, is a calcimimetic that functions as a CaSR agonist. |
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