| Identification | More | [Name]
2-Chlorotritylchloride polymer resin | [CAS]
42074-68-0 | [Synonyms]
2,4-DIMETHOXY-4'-(CARBOXYMETHYLOXY)-BENZHYDRYLAMINE HANDLE LINKED TO 2-CHLOROTRITYL RESIN
2,A-DICHLORO TRIPHENYL METHANE
2,ALPHA-DICHLOROBENZHYDRYL-POLYSTYRENE CROSSLINKED WITH DIVINYLBENZENE
2,ALPHA-DICHLOROBENZHYDRYLPOLYSTYRENE DIVINYLBENZENE COPOLYMER
2-CHLOROPHENYLDIPHENYLMETHYL CHLORIDE
2-CHLOROTRIPHENYL CHLOROMETHANE
2-CHLOROTRIPHENYL CHLOROMETHANE RESIN
2-CHLOROTRITYL CHLORIDE
2-CHLOROTRITYL CHLORIDE ON POLYSTYRENE RESIN
2-CHLOROTRITYL CHLORIDE, POLYMER-BOUND
2-CHLOROTRITYLCHLORIDE POLYMER RESIN
2-CHLOROTRITYLCHLORIDE PS RESIN
2-CHLOROTRITYL CHLORIDE RESIN
2-CHLOROTRITYL KNORR RESIN
2-CHLOROTRITYL RESIN
2-CL-(TRT)-CL RESIN
2-CLTRT RESIN
2CT-CL RESIN
2CT-CL RESIN 100
2CT-CL RESIN 200 | [EINECS(EC#)]
255-647-3 | [Molecular Formula]
C19H14Cl2 | [MDL Number]
MFCD00161760 | [Molecular Weight]
313.226 | [MOL File]
42074-68-0.mol |
| Chemical Properties | Back Directory | [Appearance]
off-white to yellow-brown beads | [Melting point ]
130-135 °C
| [Boiling point ]
421.3±40.0 °C(Predicted) | [density ]
1.222±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
Soluble in Chloroform, methanol and dichloromethane, insoluble in water | [form ]
Powder | [color ]
Pale yellow crystalline powder | [BRN ]
1983914 | [CAS DataBase Reference]
42074-68-0(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
3261 | [WGK Germany ]
3
| [F ]
10-21 | [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29039990 |
| Hazard Information | Back Directory | [Chemical Properties]
off-white to yellow or brown beads | [Uses]
2-Chlorotrityl Chloride is used in convergent peptide synthesis. 2-Chlorotrityl Chloride is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. | [Uses]
Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA. | [Application]
2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA. | [Preparation]
2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product. | [Biotechnological Applications]
The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed. |
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