| Identification | More | [Name]
R-(-)-Apomorphine | [CAS]
41372-20-7 | [Synonyms]
6a-beta-aporphine-10,11-diol
APOMORPHINE HYDROCHLORIDE, HEMIHYDRATE
(r)-5,6,6a,7-tetrahydro-6-methyl-4h-dibenzo[de,g]quinoline-10,11-diol
r-(-)-apomorphine
R-(-)-APOMORPHINE HYDROCHLORIDE HEMIHYDRATE
4H-Dibenzode,gquinoline-10,11-diol, 5,6,6a,7-tetrahydro-6-methyl-, hydrochloride, hydrate (2:1), (6aR)-
APOMORPHINEHCLHEMIHYDRATE
APOMORPHINEHYDROCHLORIDE,HEMIHYDRATE,USP
Apomophine hydrochloride
R-(-)-Apomorphine hemihydrate hydrochloride
Apomorphine hydrochloride R-(-)- | [EINECS(EC#)]
627-402-4 | [Molecular Formula]
C17H17NO2 | [MDL Number]
MFCD00150904 | [Molecular Weight]
267.32 | [MOL File]
41372-20-7.mol |
| Chemical Properties | Back Directory | [Melting point ]
285-287 °C(lit.) | [alpha ]
-48 º (c=1, H2O) | [storage temp. ]
Refrigerator | [solubility ]
H2O: ~10 mg/mL, clear, yellow-green
| [form ]
calcined
| [color ]
white to gray
| [PH]
pH(10g/l, 25℃) : 4.0～5.0 | [Merck ]
13,751 | [Stability:]
Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 week. | [CAS DataBase Reference]
41372-20-7(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R22:Harmful if swallowed. | [Safety Statements ]
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2811 6.1/PG 3
| [WGK Germany ]
3
| [HS Code ]
2933997000 |
| Hazard Information | Back Directory | [Description]
Apomorphine (41372-20-7) is an archetypal dopamine pan-receptor agonist. Displays anti-Parkinsons activity in vivo.1 Protects against MPTP-induced neurotoxicity in a mouse mode1,2 In clinical use for Parkinson’s disease.4,5 | [Chemical Properties]
Off-White Solid | [Uses]
R-(?)-Apomorphine hydrochloride hemihydrate is a nonselective dopamine agonist with anti-Parkinsonian and neuroprotective effects in vivo. | [Uses]
Dopamine (D1 and D2) receptor agonist. Emetic. Antiparkinsonian. | [Uses]
emetic, antiparkinsonian, erextile dysfunction therapy | [Brand name]
Apokyn
(Vernalis). | [Purification Methods]
Crystallise the salt from H2O (hemihydrate) and from EtOH. Crystals turn green on exposure to light. (see previous entry). NARCOTIC. | [References]
1) Merck Index 14:746
2) Millan et al. (2002), Differential actions of antiparkinson agents at multiple classes of monoaminergic receptor. I. A multivariate analysis of the binding profiles of 14 drugs at 21 native and cloned human receptor subtypes; J. Pharmacol. Exp. Therap., 303 791
3) Grunblatt et al. (1999), Apomorphine protects against MPTP-induced neurotoxicity in mice.; Mov. Discord, 14 612
4) Auffret et al. (2017), Apomorphine pump in advanced Parkinson’s disease: Effects on motor and nonmotor symptoms with brain metabolism correlations; J. Neurol. Sci, 372 279
5) Jenner and Katzenschlager (2016), Apomorphine – pharmacological properties and clinical trials in Parkinson’s disease; Parkinsonism. Related. Disord., 33 Suppl. 1:S13 |
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