| Identification | Back Directory | [Name]
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate | [CAS]
40592-88-9 | [Synonyms]
C34
TLR4-C34
TLR4-IN-C34
2-Acetamidopyranoside
Isopropyl 2-acetamido-3,4,6-tri-O-acetyl-2-deoxy-α-D-glucopyranoside
ISOPROPYL 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSIDE 3,4,6-TRIACETATE
Isopropyl 2-(acetylamino)-2-deoxy á-D-glucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-a-Dglucopyranoside 3,4,6-triacetate
1-Methylethyl 2-(acetylamino)-2-deoxy-α-D-glucopyranoside 3,4,6-triacetate
Isopropyl 2-acetamido-2-deoxy-3,4,6-tri-O-acetyl-alpha-D-glucopyranoside, Min. 98% | [Molecular Formula]
C17H27NO9 | [MDL Number]
MFCD28053519 | [MOL File]
40592-88-9.mol | [Molecular Weight]
389.398 |
| Hazard Information | Back Directory | [Uses]
TLR4-IN-C34 is a new class of toll-like receptor 4 (TLR4) inhibitors, which are potential anti-inflammatory agents. | [General Description]
TLR4-IN-C34 is an inhibitor of toll-like receptor 4 (TLR4) in vitro and in vivo. | [Biological Activity]
c34 is a 2-acetamidopyranoside that inhibits tlr4 signaling in enterocytes and macrophages in vitro when used at 10 μm. it does not affect signaling through either tlr2 or tlr9[1,2].c34, used at 1 mg/kg can reduce systemic inflammation in mouse models of endotoxemia and necrotizing enterocolitis[1].c34 markedly decreases the basal expression of tnfα, as well as lps-induced inos and tnfα expression, in intestinal tissue isolated from patients with necrotizing enterocolitis[1].[1]. neal m d, jia h, eyer b, et al. discovery and validation of a new class of small molecule toll-like receptor 4 (tlr4) inhibitors. plos one, 2013, 8(6): e65779.[2]. wipf p, eyer b r, yamaguchi y, et al. synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (tlr4). tetrahedron letters, 2015, 56(23): 3097-3100. | [Biochem/physiol Actions]
TLR4-IN-C34 is a potent and specific inhibitor of toll-like receptor 4 (TLR4), which inhibits TLR4 signaling in vivo and in vitro. TLR4-IN-C34, also known as C34, is an aminomonosaccharide that inhibits TLR4 signaling by docking with the hydrophobic pocket of the TLR4 co-receptor, myeloid differentiation protein-2 (MD-2). C34 has been shown to diminish the severity of experimental necrotizing enterocolitis (NEC). | [storage]
Store at -20°C |
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Sigma-Aldrich
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