| Identification | More | [Name]
4-Fluoroacetophenone | [CAS]
403-42-9 | [Synonyms]
1-(4-FLUOROPHENYL)ETHANONE
4'-FLUOROACETOPHENONE
4-FLUOROACETOPHENONE
4-FLUOROCETOPHENONE
AKOS BBS-00003234
LABOTEST-BB LT01148215
P-FLUOROACETOPHENONE
1-(4-fluorophenyl)-ethanon
Acetophenone, 4'-fluoro-
para-Fluoroacetophenone
1-(4-Fluorophenyl)ethan-1-one
Fluoroacetophenone color less liq
Fluoroacetophenone3
4'-Fluoroacetophenone 1-(4-Fluorophenyl)ethan-1-one 1-(4-Fluorophenyl)ethanone
4-Fluoroacetophenone,99%
p-Fluoro
4'-Fluoroacetophenone 99%
Ethanone, 1-(4-fluorophenyl)-
1-Acetyl-4-fluorobenzene
4-Acetylphenyl fluoride | [EINECS(EC#)]
206-960-9 | [Molecular Formula]
C8H7FO | [MDL Number]
MFCD00000354 | [Molecular Weight]
138.14 | [MOL File]
403-42-9.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear colorless to slightly yellow liquid | [Melting point ]
4 °C
| [Boiling point ]
77-78 °C10 mm Hg(lit.)
| [density ]
1.143 g/mL at 20 °C(lit.)
| [refractive index ]
n20/D 1.511(lit.)
| [Fp ]
160 °F
| [storage temp. ]
Sealed in dry,Room Temperature | [solubility ]
Chloroform, Ethyl Acetate | [form ]
Liquid | [color ]
Clear colorless to slightly yellow | [Specific Gravity]
1.138 | [Detection Methods]
GC,NMR | [BRN ]
386013 | [InChIKey]
ZDPAWHACYDRYIW-UHFFFAOYSA-N | [CAS DataBase Reference]
403-42-9(CAS DataBase Reference) | [NIST Chemistry Reference]
Ethanone, 1-(4-fluorophenyl)-(403-42-9) | [EPA Substance Registry System]
403-42-9(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing .
S23:Do not breathe gas/fumes/vapor/spray (appropriate wording to be specified by the manufacturer) . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [TSCA ]
T | [HazardClass ]
IRRITANT | [HS Code ]
29147090 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear colorless to slightly yellow liquid | [Uses]
4’Fluoroacetophenone is an intermediate used for the synthetic preparation of various pharmaceutical good and agricultural products. | [Synthesis]
General procedure: Oximes (1.0 mmol), Amberlyst-15 (0.02 g), FPA53-NO2(0.02 g), and solvent (1.5 mL) were introduced into a 25-cm-high, 90-mL autoclave with a glass tube inside equipped with magnetic stirrer (Scheme 2). Then the autoclave was charged with oxygen to 0.1 MPa. The reaction mixture was stirred at desirable temperature for special time. Progress of the reaction was monitored by thin-layer chromatography (TLC) or gas chromatography (GC). After the reaction, the resin (Amberlyst-15 and FPA53-NO2) was separated from the reaction mixture by filtration and extracted with 3 mL CH3CN (2 1.5 ml). The solvent was removed under reduced pressure. The residue was further purified by column chromatography on silica gel (300 mesh) with hexane/ethyl acetate to give the corresponding carbonyl compounds. |
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